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Mouse Anti-TRIM9 Recombinant Antibody (CBYJT-4837) (CBMAB-T4380-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM9 (Tripartite Motif Containing 9). The antibody can be used for immunoassay techniques, such as WB, FC.
See all TRIM9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4837
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 284-669 of human TRIM9 (NP_443210) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 284-669

Target

Full Name
tripartite motif-containing 9
Introduction
TRIM9 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to cytoplasmic bodies. Its function has not been identified.
Entrez Gene ID
114088
UniProt ID
Q9C026
Alternative Names
Tripartite Motif Containing 9; RING-Type E3 Ubiquitin Transferase TRIM9; Tripartite Motif-Containing Protein 9; RING Finger Protein 91; RNF91; E3 Ubiquitin-Protein Ligase TRIM9
Function
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cell projection, dendrite
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Synapse
Cytoplasm, cytoskeleton
Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity).
Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810).
PTM
Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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