TSLP

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

TSLP Gene(Protein Coding) Thymic Stromal Lymphopoietin

Isoform 1
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Isoform 2
May act as an antimicrobial peptide in the oral cavity and on the skin.

Biological Process antimicrobial humoral immune response mediated by antimicrobial peptide Source:UniProtKB
Biological Process defense response to fungus Source:UniProtKB
Biological Process defense response to Gram-negative bacterium Source:UniProtKB
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of chemokine (C-C motif) ligand 1 production Source:UniProtKB1 Publication
Biological Process positive regulation of chemokine production Source:UniProtKB1 Publication
Biological Process positive regulation of cytokine-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of granulocyte colony-stimulating factor production Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-13 production Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-5 production Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-6 production Source:UniProtKB1 Publication
Biological Process positive regulation of mast cell activation Source:UniProtKB1 Publication
Biological Process positive regulation of receptor signaling pathway via STAT Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication

Secreted