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Rabbit Anti-TSLP Recombinant Antibody (D7U1X) (CBMAB-CP2881-LY)

The product is antibody recognizes TSLP. The antibody D7U1X immunoassay techniques such as: WB.
See all TSLP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D7U1X
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant human TSLP protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TSLP Gene(Protein Coding) Thymic Stromal Lymphopoietin
Introduction
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Entrez Gene ID
85480
UniProt ID
Q969D9
Alternative Names
Thymic Stromal Lymphopoietin;
Function
Isoform 1
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Isoform 2
May act as an antimicrobial peptide in the oral cavity and on the skin.
Biological Process
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptide Source:UniProtKB
Biological Process defense response to fungus Source:UniProtKB
Biological Process defense response to Gram-negative bacterium Source:UniProtKB
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of chemokine (C-C motif) ligand 1 production Source:UniProtKB1 Publication
Biological Process positive regulation of chemokine production Source:UniProtKB1 Publication
Biological Process positive regulation of cytokine-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of granulocyte colony-stimulating factor production Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-13 production Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-5 production Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-6 production Source:UniProtKB1 Publication
Biological Process positive regulation of mast cell activation Source:UniProtKB1 Publication
Biological Process positive regulation of receptor signaling pathway via STAT Source:UniProtKB1 Publication
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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