UBASH3B

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq]

Full Name

ubiquitin associated and SH3 domain containing, B

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Biological Process

Biological Process collagen-activated tyrosine kinase receptor signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of bone resorption Source:GO_Central1 Publication
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process negative regulation of platelet aggregation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:GO_Central1 Publication
Biological Process negative regulation of signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-tyrosine dephosphorylation Source:GO_Central1 Publication
Biological Process platelet aggregation Source:GO_Central1 Publication
Biological Process regulation of osteoclast differentiation Source:GO_Central1 Publication
Biological Process regulation of protein binding Source:Ensembl
Biological Process regulation of release of sequestered calcium ion into cytosol Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Nucleus