Human Recombinant UBASH3B protein, His Tag (V2LY-0526-LY7007)

Name: Human Recombinant UBASH3B protein, His Tag
SKU: V2LY-0526-LY7007
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant UBASH3B protein, His Tag consist of Amino Acid: 382-649 and predicts a molecular mass of 32 kDa.

Molecule Mass

32 kDa

Sequence

Amino Acid: 382-649

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glycerol, TCEP

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

ubiquitin associated and SH3 domain containing, B

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Biological Process

Biological Process collagen-activated tyrosine kinase receptor signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of bone resorption Source:GO_Central1 Publication
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process negative regulation of platelet aggregation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:GO_Central1 Publication
Biological Process negative regulation of signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-tyrosine dephosphorylation Source:GO_Central1 Publication
Biological Process platelet aggregation Source:GO_Central1 Publication
Biological Process regulation of osteoclast differentiation Source:GO_Central1 Publication
Biological Process regulation of protein binding Source:Ensembl
Biological Process regulation of release of sequestered calcium ion into cytosol Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Mouse Anti-UBASH3B Recombinant Antibody (CBFYU-044) (CAT#: CBMAB-U0044-FY)

Mouse Anti-UBASH3B Recombinant Antibody (CBXS-2198) (CAT#: CBMAB-S4960-CQ)

Mouse Anti-UBASH3B Recombinant Antibody (3G7) (CAT#: CBMAB-A9697-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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