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Rabbit Anti-UBASH3B Recombinant Antibody (CBXS-1432) (CBMAB-S4290-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1432
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin associated and SH3 domain containing, B
Introduction
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Entrez Gene ID
84959
UniProt ID
Q8TF42
Alternative Names
Ubiquitin Associated And SH3 Domain Containing B; T-Cell Ubiquitin Ligand 2; SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate; Suppressor Of T-Cell Receptor Signaling 1; Tyrosine-Protein Phosphatase STS1/TULA2; Cbl-Interacting Protein P70; TULA-2; STS-1; STS1;
Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Biological Process
Biological Process collagen-activated tyrosine kinase receptor signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of bone resorption Source:GO_Central1 Publication
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process negative regulation of platelet aggregation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:GO_Central1 Publication
Biological Process negative regulation of signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-tyrosine dephosphorylation Source:GO_Central1 Publication
Biological Process platelet aggregation Source:GO_Central1 Publication
Biological Process regulation of osteoclast differentiation Source:GO_Central1 Publication
Biological Process regulation of protein binding Source:Ensembl
Biological Process regulation of release of sequestered calcium ion into cytosol Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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