Mouse Anti-UBASH3B Recombinant Antibody (CBXS-2198) (CBMAB-S4960-CQ)

Name: Mouse Anti-UBASH3B Recombinant Antibody (CBXS-2198)
SKU: CBMAB-S4960-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2198

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ubiquitin associated and SH3 domain containing, B

Introduction

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.

Entrez Gene ID

Human	84959
Mouse	72828
Rat	315579

UniProt ID

Human	Q8TF42
Mouse	Q8BGG7
Rat	F1LV21

Alternative Names

Ubiquitin Associated And SH3 Domain Containing B; T-Cell Ubiquitin Ligand 2; SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate; Suppressor Of T-Cell Receptor Signaling 1; Tyrosine-Protein Phosphatase STS1/TULA2; Cbl-Interacting Protein P70; TULA-2; STS-1; STS1;

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Biological Process

Biological Process collagen-activated tyrosine kinase receptor signaling pathway Source:GO_Central1 Publication
Biological Process negative regulation of bone resorption Source:GO_Central1 Publication
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process negative regulation of platelet aggregation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:GO_Central1 Publication
Biological Process negative regulation of signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-tyrosine dephosphorylation Source:GO_Central1 Publication
Biological Process platelet aggregation Source:GO_Central1 Publication
Biological Process regulation of osteoclast differentiation Source:GO_Central1 Publication
Biological Process regulation of protein binding Source:Ensembl
Biological Process regulation of release of sequestered calcium ion into cytosol Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-UBASH3B Recombinant Antibody (CBXS-1432) (CAT#: CBMAB-S4290-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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