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UBTF

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM
Full Name
upstream binding transcription factor, RNA polymerase I
Function
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Biological Process
Biological Process positive regulation of transcription by RNA polymerase I Source:UniProtKB
Biological Process transcription by RNA polymerase I Source:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase I promoter Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Nucleus, nucleolus
Involvement in disease
Neurodegeneration, childhood-onset, with brain atrophy (CONDBA):
An autosomal dominant neurodegenerative disease with onset in childhood, characterized by progressive cortical atrophy, developmental delay, developmental regression, loss of motor skills and ambulation, absence of language, and intellectual disability.
PTM
Phosphorylated and activated by PIK3CA.
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Anti-UBTF antibodies

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Mouse Anti-UBTF Recombinant Antibody (CBFYU-240) (CBMAB-U0240-FY)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYU-240
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-UBTF Recombinant Antibody (6C6) (CBMAB-A9751-LY)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 6C6
Application*: WB, E
Datasheet SDS

Mouse Anti-UBTF Recombinant Antibody (2D8) (CBMAB-A9749-LY)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2D8
Application*: WB, E
Datasheet SDS

Mouse Anti-UBTF Recombinant Antibody (2C6) (CBMAB-A9748-LY)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 2C6
Application*: WB, E
Datasheet SDS

Mouse Anti-UBTF Recombinant Antibody (V2-619178) (CBMAB-A9747-LY)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-619178
Application*: WB, E
Datasheet SDS

Mouse Anti-UBTF Monoclonal Antibody (6B6) (CBMAB-1684-YC)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6B6
Application*: E, IC, IF, P, WB
Datasheet SDS

Mouse Anti-UBTF Recombinant Antibody (CBFYU-242) (CBMAB-U0242-FY)

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Target: UBTF
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYU-242
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-UBTF Recombinant Antibody (CBFYU-241) (CBMAB-U0241-FY)

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Target: UBTF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-241
Application*: E, IC, IH, WB
Datasheet SDS

Rabbit Anti-UBTF Recombinant Antibody (CBFYU-239) (CBMAB-U0239-FY)

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Target: UBTF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYU-239
Application*: F, IC, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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