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Mouse Anti-UBTF Monoclonal Antibody (6B6) (CBMAB-1684-YC)

Provided herein is a mouse monoclonal antibody against Human UBTF. The antibody, clone 6B6, can be used for immunoassay techniques, such as ELISA, ICC, IF, IHC-P and WB.
See all UBTF antibodies
Published Data
Fig.1 UBF1 and PICT-1 were stained using Cy5 (orange), FITC (green) and Cy3 (red)-coupled secondary antibodies.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
6B6
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, IHC-P, WB

Basic Information

Immunogen
Partial recombinant protein UBTF (NP_055048, aa 551-650) with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
upstream binding transcription factor, RNA polymerase I
Introduction
UBTF is a member of the HMG-box DNA-binding protein family which plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. UBTF may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation.
Entrez Gene ID
7343
UniProt ID
P17480
Alternative Names
UBF; UBF1; UBF2; UBF-1; CONDBA; NOR-90
Function
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Biological Process
Biological Process positive regulation of transcription by RNA polymerase I Source:UniProtKB
Biological Process transcription by RNA polymerase I Source:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase I promoter Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Nucleus, nucleolus
Involvement in disease
Neurodegeneration, childhood-onset, with brain atrophy (CONDBA):
An autosomal dominant neurodegenerative disease with onset in childhood, characterized by progressive cortical atrophy, developmental delay, developmental regression, loss of motor skills and ambulation, absence of language, and intellectual disability.
PTM
Phosphorylated and activated by PIK3CA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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