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VPS26A

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Full Name
vacuolar protein sorting 26 homolog A (S. pombe)
Function
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903).
Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922).
Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227).
Required for the endosomal localization of TBC1D5 (PubMed:20923837).
Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231).
Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403).
Involved in recycling of ADRB2 (PubMed:21602791).
Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).
Biological Process
Biological Process endocytic recycling Source:UniProtKB1 Publication
Biological Process intracellular protein transport Source:GO_Central1 Publication
Biological Process regulation of macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process retrograde transport, endosome to Golgi Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Endosome membrane
Early endosome
Localizes to tubular profiles adjacent to endosomes (PubMed:15078903).
Predominantly found in early not late endosomes (By similarity).

Anti-VPS26A antibodies

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Target: VPS26A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCV-115
Application*: E, WB
Target: VPS26A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL2287
Application*: WB, IC, IF
Target: VPS26A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCV-114
Application*: WB, IP, IC, IF
Target: VPS26A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCV-113
Application*: WB, E, F
Target: VPS26A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C4
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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