WRB

This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

tryptophan rich basic protein

Function

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542).

Biological Process

Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process tail-anchored membrane protein insertion into ER membrane Source:UniProtKB1 Publication

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 1-8
Helical: 9-29
Cytoplasmic: 30-99
Helical: 100-120
Lumenal: 121-148
Helical: 149-169
Cytoplasmic: 170-174