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Mouse Anti-WRB Recombinant Antibody (2A3) (CBMAB-A9943-LY)

The product is antibody recognizes WRB. The antibody 2A3 immunoassay techniques such as: WB, ELISA.
See all WRB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
WRB (NP_004618, 29 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tryptophan rich basic protein
Introduction
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
7485
UniProt ID
O00258
Alternative Names
CHD5
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542).
Biological Process
Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process tail-anchored membrane protein insertion into ER membrane Source:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 1-8
Helical: 9-29
Cytoplasmic: 30-99
Helical: 100-120
Lumenal: 121-148
Helical: 149-169
Cytoplasmic: 170-174
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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