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Mouse Anti-WRB Recombinant Antibody (11C959) (CBMAB-W0002-WJ)

This product is a mouse antibody that recognizes WRB. The antibody 11C959 can be used for immunoassay techniques such as: WB.
See all WRB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11C959
Antibody Isotype
IgG2a, к
Application
WB

Basic Information

Immunogen
Partial recombinant protein corresponding to a portion of amino acids within aa29-102 of human WRB with GST tag. MW of GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tryptophan rich basic protein
Introduction
WRB is a protein-coding gene which located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). Diseases associated with WRB include Heart Disease and Down Syndrome.
Entrez Gene ID
7485
UniProt ID
O00258
Alternative Names
CHD5; GET1
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542).
Biological Process
Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process tail-anchored membrane protein insertion into ER membrane Source:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 1-8
Helical: 9-29
Cytoplasmic: 30-99
Helical: 100-120
Lumenal: 121-148
Helical: 149-169
Cytoplasmic: 170-174
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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