Mouse Anti-WRB Recombinant Antibody (11C959) (CBMAB-W0002-WJ)

Name: Mouse Anti-WRB Recombinant Antibody (11C959)
SKU: CBMAB-W0002-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

11C959

Application

Immunogen

Partial recombinant protein corresponding to a portion of amino acids within aa29-102 of human WRB with GST tag. MW of GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG2a, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

tryptophan rich basic protein

Introduction

WRB is a protein-coding gene which located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). Diseases associated with WRB include Heart Disease and Down Syndrome.

Entrez Gene ID

7485

UniProt ID

O00258

Alternative Names

CHD5; GET1

Function

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539).
Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542).

Biological Process

Biological Process protein insertion into ER membrane Source:UniProtKB1 Publication
Biological Process protein stabilization Source:UniProtKB2 Publications
Biological Process tail-anchored membrane protein insertion into ER membrane Source:UniProtKB1 Publication

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 1-8
Helical: 9-29
Cytoplasmic: 30-99
Helical: 100-120
Lumenal: 121-148
Helical: 149-169
Cytoplasmic: 170-174

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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