YWHAH

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

14-3-3 protein eta

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Biological Process glucocorticoid catabolic process Source:UniProtKB1 Publication
Biological Process glucocorticoid receptor signaling pathway Source:UniProtKB1 Publication
Biological Process intracellular protein transport Source:UniProtKB
Biological Process membrane depolarization during action potential Source:BHF-UCL1 Publication
Biological Process negative regulation of dendrite morphogenesis Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process presynaptic modulation of chemical synaptic transmission Source:Ensembl
Biological Process protein localization Source:GO_Central1 Publication
Biological Process regulation of neuron differentiation Source:UniProtKB
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process regulation of sodium ion transport Source:BHF-UCL1 Publication
Biological Process regulation of synaptic plasticity Source:UniProtKB
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process substantia nigra development Source:UniProtKB1 Publication

cerebellar granule cell to Purkinje cell synapse
cytoplasm
cytosol
extracellular exosome
intercalated disc
plasma membrane
presynapse

Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.