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Mouse Anti-YWHAH Recombinant Antibody (CBMAB-BR497LY)

The product is antibody recognizes YWHAH. The antibody immunoassay techniques such as: IF, IHC, WB.
See all YWHAH antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cattle, Dog, Horse, Mouse, Rat
Antibody Isotype
IgG
Application
IF: 1:1000 dilution, IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
Full length human recombinant 14.3.3? (eta) protein expressed in and purified from E.coli.
Specificity
Human, Cattle, Dog, Horse, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
5mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
14-3-3 protein eta
Introduction
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Entrez Gene ID
Human7533
Mouse22629
Rat25576
Dog100687866
Cattle282126
Horse100062878
UniProt ID
HumanQ04917
MouseP68510
RatP68511
DogA0A8C0PKM7
CattleP68509
HorseF7CYG2
Alternative Names
14-3-3 protein eta;Protein AS1;YWHAH;YWHA1;
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Biological Process
Biological Process glucocorticoid catabolic process Source:UniProtKB1 Publication
Biological Process glucocorticoid receptor signaling pathway Source:UniProtKB1 Publication
Biological Process intracellular protein transport Source:UniProtKB
Biological Process membrane depolarization during action potential Source:BHF-UCL1 Publication
Biological Process negative regulation of dendrite morphogenesis Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process presynaptic modulation of chemical synaptic transmission Source:Ensembl
Biological Process protein localization Source:GO_Central1 Publication
Biological Process regulation of neuron differentiation Source:UniProtKB
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process regulation of sodium ion transport Source:BHF-UCL1 Publication
Biological Process regulation of synaptic plasticity Source:UniProtKB
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process substantia nigra development Source:UniProtKB1 Publication
Cellular Location
cerebellar granule cell to Purkinje cell synapse
cytoplasm
cytosol
extracellular exosome
intercalated disc
plasma membrane
presynapse
PTM
Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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