Mouse Anti-YWHAH Recombinant Antibody (15H205) (CBMAB-1236-LY)

Name: Mouse Anti-YWHAH Recombinant Antibody (15H205)
SKU: CBMAB-1236-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

15H205

Application

WB, IF

Immunogen

Human 14-3-3 eta

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

14-3-3 protein eta

Introduction

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Entrez Gene ID

Human	7533
Mouse	22629
Rat	25576

UniProt ID

Human	Q04917
Mouse	P68510
Rat	P68511

Alternative Names

YWHA1

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Biological Process

Biological Process glucocorticoid catabolic process Source:UniProtKB1 Publication
Biological Process glucocorticoid receptor signaling pathway Source:UniProtKB1 Publication
Biological Process intracellular protein transport Source:UniProtKB
Biological Process membrane depolarization during action potential Source:BHF-UCL1 Publication
Biological Process negative regulation of dendrite morphogenesis Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process presynaptic modulation of chemical synaptic transmission Source:Ensembl
Biological Process protein localization Source:GO_Central1 Publication
Biological Process regulation of neuron differentiation Source:UniProtKB
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process regulation of sodium ion transport Source:BHF-UCL1 Publication
Biological Process regulation of synaptic plasticity Source:UniProtKB
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process substantia nigra development Source:UniProtKB1 Publication

Cellular Location

cerebellar granule cell to Purkinje cell synapse
cytoplasm
cytosol
extracellular exosome
intercalated disc
plasma membrane
presynapse

PTM

Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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