ZDHHC2

ZDHHC2 (Zinc Finger DHHC-Type Containing 2) is a Protein Coding gene. Among its related pathways are Surfactant metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include receptor activity and palmitoyltransferase activity. An important paralog of this gene is ZDHHC2.

Full Name

Zinc Finger DHHC-Type Containing 2

Function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055).
Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).
In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity).
In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity).
Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity).
Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921).
Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824).
Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844).
(Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.

Biological Process

Biological Process peptidyl-L-cysteine S-palmitoylation Source:UniProtKB1 Publication
Biological Process positive regulation of AMPA glutamate receptor clustering Source:UniProtKB
Biological Process positive regulation of endosome to plasma membrane protein transport Source:UniProtKB
Biological Process positive regulation of long-term synaptic potentiation Source:UniProtKB
Biological Process protein localization to plasma membrane Source:UniProtKB
Biological Process protein localization to postsynaptic membrane Source:UniProtKB
Biological Process protein metabolic process Source:Reactome
Biological Process protein palmitoylation Source:UniProtKB1 Publication
Biological Process protein targeting to membrane Source:GO_Central1 Publication
Biological Process regulation of cell-cell adhesion Source:UniProtKB1 Publication
Biological Process regulation of neuronal synaptic plasticity Source:UniProtKB
Biological Process regulation of protein catabolic process Source:UniProtKB1 Publication
Biological Process regulation of protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process synaptic vesicle maturation Source:GO_Central1 Publication

Cellular Location

Postsynaptic density
Postsynaptic recycling endosome membrane
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus membrane
Translocates to postsynaptic density when synaptic activity decreases.

Topology

Cytoplasmic: 1-16
Helical: 17-37
Lumenal: 38-54
Helical: 55-75
Cytoplasmic: 76-170
Helical: 171-191
Lumenal: 192-208
Helical: 209-229
Cytoplasmic: 230-367

PTM

Autopalmitoylated.