Mouse Anti-ABCC5 Recombinant Antibody (V2-179028) (CBMAB-A0264-YC)

Provided herein is a Mouse monoclonal antibody against Human ATP Binding Cassette Subfamily C Member 5. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ABCC5 antibodies

Published Data

Mouse Anti-ABCC5 Recombinant Antibody (1B12) (CBMAB-A0264-YC) in IF

Immunofluorescence microscopy of cryosections of human pre-term placenta. Detection of MRP5 in pre-term placenta indicating the basal localization of this transport protein. ...View More

Zu Schwabedissen, H. E. M., Grube, M., Heydrich, B., Linnemann, K., Fusch, C., Kroemer, H. K., & Jedlitschky, G. (2005). Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. The American journal of pathology, 166(1), 39-48.

Mouse Anti-ABCC5 Recombinant Antibody (1B12) (CBMAB-A0264-YC) in IHC

Detection of MRP5 in differentiating cytotrophoblasts in culture.mmunohistochemical detection of MRP5 with the AMF antibody (brown staining) in isolated cytotrophoblasts after six days. ...View More

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

V2-179028

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

ABCC5 (NP_005679. 2, 760-846 aa) partial recombinant protein with GST tag. Immunogen sequence: CITERGTHEE LMNLNGDYAT IFNNLLLGET PPVEINSKKE TSGSQKKSQD KGPKTGSVKK EKAVKPEEGQ LVQLEEKGQG SVPWSVY

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 760-846

Target

Full Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Introduction

ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN

Entrez Gene ID

10057

UniProt ID

O15440

Alternative Names

ATP Binding Cassette Subfamily C Member 5; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5; Multi-Specific Organic Anion Transporter C; MOAT-C; PABC11; MRP5; SMRP;

Function

Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway.

Biological Process

cAMP transport
cGMP transport
Export across plasma membrane
Folate transmembrane transport
Glutathione transmembrane transport
Heme transmembrane transport
Hyaluronan biosynthetic process
Purine nucleotide transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport

Cellular Location

Endosome membrane; Golgi apparatus lumen; Basolateral cell membrane; Cytoplasmic granule

References

Ji, G., He, S., Huang, C., Gong, Y., Li, X., & Zhou, L. (2021). Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway. International journal of biological sciences, 17(7), 1613.

Chen, J., Wang, Z., Gao, S., Wu, K., Bai, F., Zhang, Q., ... & Liu, Y. (2021). Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer. Cancer cell international, 21(1), 1-10.

Wang, H., Liu, S., Xun, X., Li, M., Lou, J., Zhang, Y., ... & Hu, X. (2021). Toxin-and species-dependent regulation of ATP-binding cassette (ABC) transporters in scallops after exposure to paralytic shellfish toxin-producing dinoflagellates. Aquatic Toxicology, 230, 105697.

He, X., Ma, J., Zhang, M., Cui, J., & Yang, H. (2020). Circ_0007031 enhances tumor progression and promotes 5-fluorouracil resistance in colorectal cancer through regulating miR-133b/ABCC5 axis. Cancer Biomarkers, (Preprint), 1-12.

Zhang, L., Li, B., Zhang, B., Zhang, H., & Suo, J. (2019). miR‑361 enhances sensitivity to 5‑fluorouracil by targeting the FOXM1‑ABCC5/10 signaling pathway in colorectal cancer. Oncology letters, 18(4), 4064-4073.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

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Rat Anti-ABCC5 Recombinant Antibody (V2-179032)

Mouse Anti-ABCC5 Recombinant Antibody (V2-179029)

Mouse Anti-ABCC5 Recombinant Antibody (V2-179031)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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