Mouse Anti-ABCC5 Recombinant Antibody (V2-179029) (CBMAB-A0265-YC)

Provided herein is a Mouse monoclonal antibody against Human ATP Binding Cassette Subfamily C Member 5. The antibody can be used for immunoassay techniques, such as WB, IHC.
See all ABCC5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

V2-179029

Antibody Isotype

IgG1

Application

WB, IHC

Basic Information

Immunogen

Full length human recombinant protein of human ABCC5 (NP_001018881) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000
IHC-P	1:150
IHC	1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.3, 1% BSA, 50% Glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Introduction

ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN

Entrez Gene ID

10057

UniProt ID

O15440

Alternative Names

ATP Binding Cassette Subfamily C Member 5; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5; Multi-Specific Organic Anion Transporter C; MOAT-C; PABC11; MRP5; SMRP;

Function

Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway.

Biological Process

cAMP transport
cGMP transport
Export across plasma membrane
Folate transmembrane transport
Glutathione transmembrane transport
Heme transmembrane transport
Hyaluronan biosynthetic process
Purine nucleotide transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport

Cellular Location

Endosome membrane; Golgi apparatus lumen; Basolateral cell membrane; Cytoplasmic granule

References

Ji, G., He, S., Huang, C., Gong, Y., Li, X., & Zhou, L. (2021). Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway. International journal of biological sciences, 17(7), 1613.

Chen, J., Wang, Z., Gao, S., Wu, K., Bai, F., Zhang, Q., ... & Liu, Y. (2021). Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer. Cancer cell international, 21(1), 1-10.

Wang, H., Liu, S., Xun, X., Li, M., Lou, J., Zhang, Y., ... & Hu, X. (2021). Toxin-and species-dependent regulation of ATP-binding cassette (ABC) transporters in scallops after exposure to paralytic shellfish toxin-producing dinoflagellates. Aquatic Toxicology, 230, 105697.

He, X., Ma, J., Zhang, M., Cui, J., & Yang, H. (2020). Circ_0007031 enhances tumor progression and promotes 5-fluorouracil resistance in colorectal cancer through regulating miR-133b/ABCC5 axis. Cancer Biomarkers, (Preprint), 1-12.

Zhang, L., Li, B., Zhang, B., Zhang, H., & Suo, J. (2019). miR‑361 enhances sensitivity to 5‑fluorouracil by targeting the FOXM1‑ABCC5/10 signaling pathway in colorectal cancer. Oncology letters, 18(4), 4064-4073.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rat Anti-ABCC5 Recombinant Antibody (V2-179034)

Rat Anti-ABCC5 Recombinant Antibody (V2-179032)

Mouse Anti-ABCC5 Recombinant Antibody (V2-179031)

Mouse Anti-ABCC5 Recombinant Antibody (V2-179028)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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