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Mouse Anti-ADCY1 Recombinant Antibody (V2-362536) (CBMAB-C5313-CQ)

This product is a mouse antibody that recognizes ADCY1. The antibody CBXC-0002 can be used for immunoassay techniques such as: ELISA.
See all ADCY1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-362536
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
C4orf6 (NP_005741, 1 a.a.-93 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.2
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenylate Cyclase 1
Introduction
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
107
UniProt ID
Q08828
Alternative Names
Adenylate Cyclase 1; Ca(2+)/Calmodulin-Activated Adenylyl Cyclase; Adenylate Cyclase 1 (Brain); ATP Pyrophosphate-Lyase 1; Adenylate Cyclase Type I; Adenylyl Cyclase 1; EC 4.6.1.1;
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
Biological Process
Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Axonogenesis
Brain development
cAMP biosynthetic process
cAMP-mediated signaling
Cellular response to calcium ion
Cellular response to forskolin
Cellular response to glucagon stimulus
Circadian rhythm
G protein-coupled receptor signaling pathway
Long-term memory
Negative regulation of inflammatory response to antigenic stimulus
Neuroinflammatory response
Positive regulation of CREB transcription factor activity
Positive regulation of long-term synaptic potentiation
Regulation of circadian rhythm
Regulation of synaptic vesicle exocytosis
Renal water homeostasis
Response to drug
Response to lithium ion
Cellular Location
Cell membrane; Cytoplasm; Membrane. Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.
Involvement in disease
Deafness, autosomal recessive, 44 (DFNB44): A form of non-syndromic deafness characterized by prelingual profound hearing loss affecting all frequencies.
PTM
N-glycosylated.

Liu, G., Zhao, H., Song, Q., Li, G., Lin, S., & Xiong, S. (2021). Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer via the upregulation of ADCY1 by regulating microRNA-127-3p. Aging (Albany NY), 13(7), 9748.

Yukina, M., Vasilyev, E., Nuralieva, N., & Troshina, E. (2021, May). Clinical case of insulinoma in patient with germline mutation in the ADCY1 gene. In Endocrine Abstracts (Vol. 73). Bioscientifica.

Doucette, A., Johnson, K., Watts, V., & Klein, A. (2021). Intrathecal Knockdown of Adenylyl Cyclase 1 Attenuates Morphine Tolerance and Withdrawal in Mice. The Journal of Pain, 22(5), 578-579.

Yang, M., Ding, Q., Zhang, M., Moon, C., & Wang, H. (2020). Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress. Neurobiology of Stress, 13, 100237.

Ma, M., Dai, J., Tang, H., Xu, T., Yu, S., Si, L., ... & Guo, J. (2019). MicroRNA-23a-3p inhibits mucosal melanoma growth and progression through targeting adenylate cyclase 1 and attenuating cAMP and MAPK pathways. Theranostics, 9(4), 945.

Zou, T., Liu, J., She, L., Chen, J., Zhu, T., Yin, J., ... & Liu, Z. (2019). A perspective profile of ADCY1 in cAMP signaling with drug-resistance in lung cancer. Journal of Cancer, 10(27), 6848.

Lerias, J., Pinto, M., Benedetto, R., Schreiber, R., Amaral, M., Aureli, M., & Kunzelmann, K. (2018). Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1. Cellular signalling, 44, 10-19.

Shahidullah, M., Mandal, A., & Delamere, N. A. (2017). A role for calcium-activated adenylate cyclase and protein kinase A in the lens Src family kinase and Na, K-ATPase response to hyposmotic stress. Investigative ophthalmology & visual science, 58(11), 4447-4456.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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