Mouse Anti-ADCY1 Recombinant Antibody (V2-179863) (CBMAB-A1240-YC)

Name: Mouse Anti-ADCY1 Recombinant Antibody (V2-179863)
SKU: CBMAB-A1240-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179863

Application

WB, ICC, IHC-P, ELISA

Immunogen

Adenylate Cyclase 1, Brain

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:5,000
IF(ICC)	1:50-1:200
IHC	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.4, 0.02% sodium azide, 50% glycerol

Buffer

PBS, pH7.4, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adenylate Cyclase 1

Introduction

ADCY1 is a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development.

Entrez Gene ID

107

UniProt ID

Q08828

Alternative Names

Adenylate Cyclase 1; Ca(2+)/Calmodulin-Activated Adenylyl Cyclase; Adenylate Cyclase 1 (Brain); ATP Pyrophosphate-Lyase 1; Adenylate Cyclase Type I; Adenylyl Cyclase 1; EC 4.6.1.1;

Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).

Biological Process

Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Axonogenesis
Brain development
cAMP biosynthetic process
cAMP-mediated signaling
Cellular response to calcium ion
Cellular response to forskolin
Cellular response to glucagon stimulus
Circadian rhythm
G protein-coupled receptor signaling pathway
Long-term memory
Negative regulation of inflammatory response to antigenic stimulus
Neuroinflammatory response
Positive regulation of CREB transcription factor activity
Positive regulation of long-term synaptic potentiation
Regulation of circadian rhythm
Regulation of synaptic vesicle exocytosis
Renal water homeostasis
Response to drug
Response to lithium ion

Cellular Location

Cell membrane; Cytoplasm; Membrane. Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.

Involvement in disease

Deafness, autosomal recessive, 44 (DFNB44): A form of non-syndromic deafness characterized by prelingual profound hearing loss affecting all frequencies.

PTM

N-glycosylated.

Liu, G., Zhao, H., Song, Q., Li, G., Lin, S., & Xiong, S. (2021). Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer via the upregulation of ADCY1 by regulating microRNA-127-3p. Aging (Albany NY), 13(7), 9748.

Yukina, M., Vasilyev, E., Nuralieva, N., & Troshina, E. (2021, May). Clinical case of insulinoma in patient with germline mutation in the ADCY1 gene. In Endocrine Abstracts (Vol. 73). Bioscientifica.

Doucette, A., Johnson, K., Watts, V., & Klein, A. (2021). Intrathecal Knockdown of Adenylyl Cyclase 1 Attenuates Morphine Tolerance and Withdrawal in Mice. The Journal of Pain, 22(5), 578-579.

Yang, M., Ding, Q., Zhang, M., Moon, C., & Wang, H. (2020). Forebrain overexpression of type 1 adenylyl cyclase promotes molecular stability and behavioral resilience to physical stress. Neurobiology of Stress, 13, 100237.

Ma, M., Dai, J., Tang, H., Xu, T., Yu, S., Si, L., ... & Guo, J. (2019). MicroRNA-23a-3p inhibits mucosal melanoma growth and progression through targeting adenylate cyclase 1 and attenuating cAMP and MAPK pathways. Theranostics, 9(4), 945.

Zou, T., Liu, J., She, L., Chen, J., Zhu, T., Yin, J., ... & Liu, Z. (2019). A perspective profile of ADCY1 in cAMP signaling with drug-resistance in lung cancer. Journal of Cancer, 10(27), 6848.

Lerias, J., Pinto, M., Benedetto, R., Schreiber, R., Amaral, M., Aureli, M., & Kunzelmann, K. (2018). Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1. Cellular signalling, 44, 10-19.

Shahidullah, M., Mandal, A., & Delamere, N. A. (2017). A role for calcium-activated adenylate cyclase and protein kinase A in the lens Src family kinase and Na, K-ATPase response to hyposmotic stress. Investigative ophthalmology & visual science, 58(11), 4447-4456.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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