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Mouse Anti-ARRB1 Recombinant Antibody (15B101) (CBMAB-A3666-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
15B101
Antibody Isotype
IgG1, κ
Application
WB, IF

Basic Information

Immunogen
Recombinant full length Human Arrestin beta-1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500
IF(ICC)2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ARRB1
Introduction
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory si
Entrez Gene ID
Human408
Mouse109689
Rat25387
UniProt ID
HumanP49407
MouseQ8BWG8
RatP29066
Alternative Names
Arrestin Beta 1; Non-Visual Arrestin-2; Arrestin 2; ARR1; Arrestin, Beta 1; Beta-Arrestin-1; Arrestin Beta-1; ARB1;
Biological Process
Activation of MAPK activity Source: Ensembl
Follicle-stimulating hormone signaling pathway Source: Ensembl
G protein-coupled receptor internalization Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Histone acetylation Source: GOC
Membrane organization Source: Reactome
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of GTPase activity Source: Ensembl
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of interleukin-8 production Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of Notch signaling pathway Source: UniProtKB
Negative regulation of protein phosphorylation Source: Ensembl
Negative regulation of protein ubiquitination Source: UniProtKB
Platelet activation Source: Reactome
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of histone acetylation Source: BHF-UCL
Positive regulation of histone H4 acetylation Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of protein ubiquitination Source: Ensembl
Positive regulation of receptor internalization Source: UniProtKB
Positive regulation of Rho protein signal transduction Source: UniProtKB
Positive regulation of smooth muscle cell apoptotic process Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Post-Golgi vesicle-mediated transport Source: Reactome
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein transport Source: UniProtKB-KW
Protein ubiquitination Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Response to drug Source: Ensembl
Stress fiber assembly Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cell membrane; Cytoplasm; Clathrin-coated pit; Pseudopodium; Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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