Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-BCL11B Recombinant Antibody (CBT2159) (V2LY-0625-LY687)


See all BCL11B antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2159
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human BCL11B (AA: 1-150) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
B CELL CLL/LYMPHOMA 11B
Entrez Gene ID
64919
UniProt ID
Q9C0K0
Function
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755).
Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611).
Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).
May also function in the P53-signaling pathway (By similarity).
Biological Process
Alpha-beta T cell differentiation Source: Ensembl
Commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
Epithelial cell morphogenesis Source: Ensembl
Hematopoietic stem cell migration Source: UniProtKB
Keratinocyte development Source: Ensembl
Lymphoid lineage cell migration into thymus Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Olfactory bulb axon guidance Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive T cell selection Source: Ensembl
Post-embryonic camera-type eye development Source: Ensembl
Regulation of keratinocyte proliferation Source: Ensembl
Regulation of lipid metabolic process Source: Ensembl
Regulation of neuron differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Striatal medium spiny neuron differentiation Source: Ensembl
T cell differentiation in thymus Source: Ensembl
T cell receptor V(D)J recombination Source: Ensembl
Thymus development Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Immunodeficiency 49 (IMD49): A form of severe combined immunodeficiency characterized by severe T-cell lymphopenia, no detectable T-cell receptor excision circles, no naive helper CD4+ T-cells, and impaired T-cell proliferative response. In addition to primary immunodeficiency, affected individuals manifest multiple abnormal systemic features, including severe delayed psychomotor development, intellectual disability, spastic quadriplegia, and craniofacial abnormalities.
Intellectual developmental disorder with speech delay, dysmorphic facies, and T-cell abnormalities (IDDSFTA): An autosomal dominant developmental disorder with onset in first months of life, and characterized by delayed psychomotor development with intellectual disability and speech delay. Additional features include autistic features, attention deficit-hyperactivity disorder, anxiety, and other behavioral abnormalities. Some patients suffer from recurrent infections, asthma and allergies.
PTM
Sumoylated with SUMO1.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BCL11B Recombinant Antibody (CBT2159)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry