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Rat Anti-BCL11B Recombinant Antibody (25B6) (CBMAB-1204-CN)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
25B6
Application
WB, IHC
Immunogen
GST-tagged recombinant full-length mouse CTIP2 Beta isoform.
Host Species
Rat
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
15 mM HEPES, pH 7.5
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 1-150
More Infomation

Target

Full Name
B CELL CLL/LYMPHOMA 11B
Introduction
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. It is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes.
Entrez Gene ID
Human64919
Mouse58208
Rat314423
Guinea pig100728663
Zebrafish100093707
Monkey705238
UniProt ID
HumanQ9C0K0
MouseQ99PV8
RatH9N1L4
Guinea pigA0A286XUZ2
ZebrafishX1WBZ3
MonkeyD3ZSY3
Alternative Names
ATL1; RIT1; CTIP2; IMD49; CTIP-2; ZNF856B; ATL1-beta; ATL1-alpha; ATL1-delta; ATL1-gamma; hRIT1-alpha
Function
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755).
Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611).
Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).
May also function in the P53-signaling pathway (By similarity).
Biological Process
Alpha-beta T cell differentiation Source: Ensembl
Commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
Epithelial cell morphogenesis Source: Ensembl
Hematopoietic stem cell migration Source: UniProtKB
Keratinocyte development Source: Ensembl
Lymphoid lineage cell migration into thymus Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Olfactory bulb axon guidance Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive T cell selection Source: Ensembl
Post-embryonic camera-type eye development Source: Ensembl
Regulation of keratinocyte proliferation Source: Ensembl
Regulation of lipid metabolic process Source: Ensembl
Regulation of neuron differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Striatal medium spiny neuron differentiation Source: Ensembl
T cell differentiation in thymus Source: Ensembl
T cell receptor V(D)J recombination Source: Ensembl
Thymus development Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Immunodeficiency 49 (IMD49): A form of severe combined immunodeficiency characterized by severe T-cell lymphopenia, no detectable T-cell receptor excision circles, no naive helper CD4+ T-cells, and impaired T-cell proliferative response. In addition to primary immunodeficiency, affected individuals manifest multiple abnormal systemic features, including severe delayed psychomotor development, intellectual disability, spastic quadriplegia, and craniofacial abnormalities.
Intellectual developmental disorder with speech delay, dysmorphic facies, and T-cell abnormalities (IDDSFTA): An autosomal dominant developmental disorder with onset in first months of life, and characterized by delayed psychomotor development with intellectual disability and speech delay. Additional features include autistic features, attention deficit-hyperactivity disorder, anxiety, and other behavioral abnormalities. Some patients suffer from recurrent infections, asthma and allergies.
PTM
Sumoylated with SUMO1.

Sidwell, T., & Rothenberg, E. V. (2021). Epigenetic Dynamics in the Function of T-Lineage Regulatory Factor Bcl11b. Frontiers in immunology, 12.

Simon, R., Wiegreffe, C., & Britsch, S. (2020). Bcl11 transcription factors regulate cortical development and function. Frontiers in molecular neuroscience, 13, 51.

Qiao, F., Wang, C., Luo, C., Wang, Y., Shao, B., Tan, J., ... & Xu, Z. (2019). A De Novo heterozygous frameshift mutation identified in BCL11B causes neurodevelopmental disorder by whole exome sequencing. Molecular genetics & genomic medicine, 7(9), e897.

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L., Matsumoto, M., ... & Rothenberg, E. V. (2018). Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nature immunology, 19(12), 1427-1440.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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