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Rabbit Anti-CAV2 Recombinant Antibody (D4A6) (CBMAB-CP0144-LY)

The product is antibody recognizes CAV2. The antibody D4A6 immunoassay techniques such as: WB,IP,IF (ICC).
See all CAV2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D4A6
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human caveolin protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Caveolin 2
Introduction
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Entrez Gene ID
Human858
Monkey706980
UniProt ID
HumanP51636
MonkeyQ2QLF3
Alternative Names
Caveolin 2; Caveolin 2 Isoform A And B; Caveolae Protein; 20-KD; Caveolin-2; CAV;
Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
Biological Process
Basement membrane organization Source: Ensembl
Caveola assembly Source: BHF-UCL
Cell differentiation Source: GO_Central
Endoplasmic reticulum organization Source: UniProtKB
Insulin receptor signaling pathway Source: BHF-UCL
Mitochondrion organization Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: UniProtKB
Negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Positive regulation by host of viral process Source: AgBase
Positive regulation by host of viral release from host cell Source: AgBase
Positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: Ensembl
Positive regulation of GTPase activity Source: BHF-UCL
Positive regulation of MAPK cascade Source: BHF-UCL
Receptor-mediated endocytosis of virus by host cell Source: CACAO
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of mitotic nuclear division Source: BHF-UCL
Skeletal muscle fiber development Source: UniProtKB
Vesicle docking Source: BHF-UCL
Vesicle fusion Source: BHF-UCL
Vesicle organization Source: BHF-UCL
Cellular Location
Cell membrane; Golgi apparatus membrane; Cytoplasm; Nucleus; Caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Topology
Cytoplasmic: 1-86
Helical: 87-107
Cytoplasmic: 108-162
PTM
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).

Liu, Y., Wang, M., Wang, D., Fay, W. P., Korthuis, R. J., & Sowa, G. (2021). Elevated post-ischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1. American Journal of Physiology-Heart and Circulatory Physiology.

Mamoor, S. (2021). Differential expression of caveolin 2 in cancers of the breast.

Kwon, H., Choi, M., Ahn, Y., & Pak, Y. (2020). N-myristoylation regulates insulin-induced phosphorylation and ubiquitination of Caveolin-2 for insulin signaling. Biochemical and Biophysical Research Communications, 532(4), 535-540.

Yang, X., Ma, L., Wei, R., Ye, T., Zhou, J., Wen, M., ... & Yang, L. (2020). Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway. Signal transduction and targeted therapy, 5(1), 1-12.

Bulacio, R. P., Nosetto, E. C., Brandoni, A., & Torres, A. M. (2019). Novel finding of caveolin‐2 in apical membranes of proximal tubule and first detection of caveolin‐2 in urine: A promising biomarker of renal disease. Journal of cellular biochemistry, 120(4), 4966-4974.

Bulacio, R. P., & Torres, A. M. (2019). Caveolin-2 in urine as a novel biomarker of renal recovery after cisplatin induced nephrotoxicity in rats. Toxicology letters, 313, 169-177.

Gerstenberger, W., Wrage, M., Kettunen, E., Pantel, K., Anttila, S., Steurer, S., & Wikman, H. (2018). Stromal caveolin-1 and caveolin-2 expression in primary tumors and lymph node metastases. Analytical cellular pathology, 2018.

Liu, F., Shangli, Z., & Hu, Z. (2018). CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway. OncoTargets and therapy, 11, 6209.

Liang, C., Shi, S., Meng, Q., Liang, D., Hua, J., Qin, Y., ... & Yu, X. (2018). MiR‐29a, targeting caveolin 2 expression, is responsible for limitation of pancreatic cancer metastasis in patients with normal level of serum CA125. International journal of cancer, 143(11), 2919-2931.

de Almeida, C. J. G. (2017). Caveolin-1 and caveolin-2 can be antagonistic partners in inflammation and beyond. Frontiers in immunology, 8, 1530.

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For research use only. Not intended for any clinical use.

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