Mouse Anti-CCR6 Recombinant Antibody (CBLC-LY-023) (CBMAB-C9422-LY)

C-C Motif Chemokine Receptor 6

CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include Limited Scleroderma and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Defensins and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity.
An important paralog of this gene is CCR7.

C-C Motif Chemokine Receptor 6; Chemokine (C-C Motif) Receptor 6; Chemokine Receptor-Like 3; LARC Receptor; C-C CKR-6; CC-CKR-6; STRL22; CKR-L3; CMKBR6; GPRCY4; CCR-6; CKRL3; GPR29;

Receptor for the C-C type chemokine CCL20 (PubMed:9169459).
Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036).
Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877).
Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636).
Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036).
The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174).
CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity).
Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).

Calcium-mediated signaling Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Cellular defense response Source: ProtInc
Chemotaxis Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
DN2 thymocyte differentiation Source: UniProtKB
DN3 thymocyte differentiation Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Humoral immune response Source: ProtInc
Immune response Source: GO_Central
Isotype switching to IgA isotypes Source: UniProtKB
Leukocyte migration involved in inflammatory response Source: UniProtKB
Lymphocyte migration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of dendritic cell chemotaxis Source: GO_Central
Positive regulation of epithelial cell migration Source: Ensembl
Positive regulation of flagellated sperm motility involved in capacitation Source: UniProtKB
Regulation of T cell migration Source: UniProtKB
Signal transduction Source: ProtInc
T cell migration Source: UniProtKB
Thymocyte migration Source: UniProtKB

Cell membrane; Cell surface

Extracellular: 1-47
Helical: 48-74
Cytoplasmic: 75-83
Helical: 84-104
Extracellular: 105-119
Helical: 120-141
Cytoplasmic: 142-159
Helical: 160-180
Extracellular: 181-211
Helical: 212-238
Cytoplasmic: 239-254
Helical: 255-279
Extracellular: 280-303
Helical: 304-321
Cytoplasmic: 322-374