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Mouse Anti-CD3D Recombinant Antibody (6B1C12F3) (CBMAB-C8080-LY)

This product is antibody recognizes CD3D. The antibody 6B1C12F3 immunoassay techniques such as: IHC-P.
See all CD3D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6B1C12F3
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Recombinant Human CD3d/CD3 delta protein. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD3d/CD3 delta
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD3d Molecule
Introduction
CD3D (CD3d Molecule) is a Protein Coding gene. Diseases associated with CD3D include Immunodeficiency 19 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are G-protein signaling N-RAS regulation pathway and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity.
An important paralog of this gene is CD3G.
Entrez Gene ID
915
UniProt ID
P04234
Alternative Names
CD3d Molecule; CD3d Antigen, Delta Polypeptide (TiT3 Complex); CD3d Molecule, Delta (CD3-TCR Complex); T-Cell Receptor T3 Delta Chain; T3D; T-Cell Surface Glycoprotein CD3 Delta Chain; CD3 Antigen, Delta Subunit;
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).

In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: GO_Central
Membrane organization Source: Reactome
Positive thymic T cell selection Source: UniProtKB
Regulation of immune response Source: Reactome
T cell receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Involvement in disease
Immunodeficiency 19 (IMD19): An autosomal recessive form of severe combined immunodeficiency characterized by onset in early infancy of recurrent bacterial, viral, and fungal infections. Patients usually have chronic diarrhea, recurrent respiratory infections, and failure to thrive. Immunologic work-up shows a T-cell negative, B-cell positive, NK-cell positive phenotype.
Topology
Extracellular: 22-105
Helical: 106-126
Cytoplasmic: 127-171
PTM
Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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