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Rabbit Anti-CD82 Recombinant Antibody (CBFYC-1451) (CBMAB-C1509-FY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-1451
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Immunogen
Recombinant Human CD82/KAI-1 Protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1:400-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD82 Molecule
Introduction
In these cells, the coprecipitation of CD81 and CD82 was not modified, suggesting that these tetraspans did not compete for association.
Entrez Gene ID
3732
UniProt ID
P27701
Alternative Names
CD82 Molecule; CD82 Antigen; Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)); Metastasis Suppressor Kangai-1; Inducible Membrane Protein R2; Tetraspanin-27; C33 Antigen; Tspan-27; TSPAN27; KAI1; SAR2
Function
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-11
Helical: 12-32
Extracellular: 33-53
Helical: 54-72
Cytoplasmic: 73-83
Helical: 84-110
Extracellular: 111-228
Helical: 229-250
Cytoplasmic: 251-267
More Infomation

Lee, J. W., Hur, J., Kwon, Y. W., Chae, C. W., Choi, J. I., Hwang, I., ... & Kim, H. S. (2021). KAI1 (CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state. Journal of Hematology & Oncology, 14(1), 1-21.

He, X., Ma, X., Wang, C., Luan, M., Li, Y., Huang, X., & Ma, K. (2021). The peptide mimicking small extracellular ring domain of CD82 inhibits tumor cell migration in vitro and metastasis in vivo. Journal of Cancer Research and Clinical Oncology, 147(7), 1927-1934.

Fernandez, L., Malrieu, M., Bénistant, C., Dosset, P., Rubinstein, E., Odintsova, E., ... & Milhiet, P. E. (2021). CD82 and Gangliosides Tune CD81 Membrane Behavior. International Journal of Molecular Sciences, 22(16), 8459.

Yan, W., Huang, J., Zhang, Q., & Zhang, J. (2021). Role of Metastasis Suppressor KAI1/CD82 in Different Cancers. Journal of Oncology, 2021.

He, X., Huang, X., Wang, C., Luan, M., Li, Y., Ma, X., & Ma, K. (2020). The peptide mimicking small extracellular ring domain of CD82 inhibits epithelial-mesenchymal transition by downregulating Wnt pathway and upregulating hippo pathway. Biochemical and Biophysical Research Communications, 533(3), 338-345.

Ma, Z., Gao, Y., Liu, W., Zheng, L., Jin, B., Duan, B., ... & Li, L. (2020). CD82 Suppresses ADAM17-Dependent E-Cadherin cleavage and cell migration in prostate cancer. Disease markers, 2020.

Huang, C., Hays, F. A., Tomasek, J. J., Benyajati, S., & Zhang, X. A. (2020). Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement. Journal of extracellular vesicles, 9(1), 1692417.

Wang, X., Zhong, W., Bu, J., Li, Y., Li, R., Nie, R., ... & Li, Y. (2019). Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer. Molecular carcinogenesis, 58(5), 674-685.

Li, W., Hu, M., Wang, C., Lu, H., Chen, F., Xu, J., ... & Lu, C. (2017). A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling. Oncogene, 36(38), 5407-5420.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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