CD82

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

CD82 Molecule

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Cell membrane

Cytoplasmic: 1-11
Helical: 12-32
Extracellular: 33-53
Helical: 54-72
Cytoplasmic: 73-83
Helical: 84-110
Extracellular: 111-228
Helical: 229-250
Cytoplasmic: 251-267