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Mouse Anti-CD82 Recombinant Antibody (CBT2028) (V2LY-0625-LY1978)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2028
Antibody Isotype
IgG1
Application
WB, IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human CD82 (AA: extra 111-228) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD82 Molecule
Entrez Gene ID
3732
UniProt ID
P27701
Function
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-11
Helical: 12-32
Extracellular: 33-53
Helical: 54-72
Cytoplasmic: 73-83
Helical: 84-110
Extracellular: 111-228
Helical: 229-250
Cytoplasmic: 251-267
More Infomation

Lee, J. W., Hur, J., Kwon, Y. W., Chae, C. W., Choi, J. I., Hwang, I., ... & Kim, H. S. (2021). KAI1 (CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state. Journal of Hematology & Oncology, 14(1), 1-21.

He, X., Ma, X., Wang, C., Luan, M., Li, Y., Huang, X., & Ma, K. (2021). The peptide mimicking small extracellular ring domain of CD82 inhibits tumor cell migration in vitro and metastasis in vivo. Journal of Cancer Research and Clinical Oncology, 147(7), 1927-1934.

Fernandez, L., Malrieu, M., Bénistant, C., Dosset, P., Rubinstein, E., Odintsova, E., ... & Milhiet, P. E. (2021). CD82 and Gangliosides Tune CD81 Membrane Behavior. International Journal of Molecular Sciences, 22(16), 8459.

Yan, W., Huang, J., Zhang, Q., & Zhang, J. (2021). Role of Metastasis Suppressor KAI1/CD82 in Different Cancers. Journal of Oncology, 2021.

He, X., Huang, X., Wang, C., Luan, M., Li, Y., Ma, X., & Ma, K. (2020). The peptide mimicking small extracellular ring domain of CD82 inhibits epithelial-mesenchymal transition by downregulating Wnt pathway and upregulating hippo pathway. Biochemical and Biophysical Research Communications, 533(3), 338-345.

Ma, Z., Gao, Y., Liu, W., Zheng, L., Jin, B., Duan, B., ... & Li, L. (2020). CD82 Suppresses ADAM17-Dependent E-Cadherin cleavage and cell migration in prostate cancer. Disease markers, 2020.

Huang, C., Hays, F. A., Tomasek, J. J., Benyajati, S., & Zhang, X. A. (2020). Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle–mediated release of ezrin to inhibit tumour cell movement. Journal of extracellular vesicles, 9(1), 1692417.

Wang, X., Zhong, W., Bu, J., Li, Y., Li, R., Nie, R., ... & Li, Y. (2019). Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer. Molecular carcinogenesis, 58(5), 674-685.

Li, W., Hu, M., Wang, C., Lu, H., Chen, F., Xu, J., ... & Lu, C. (2017). A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling. Oncogene, 36(38), 5407-5420.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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