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Mouse Anti-CDH3 Recombinant Antibody (CBXC-2083) (CBMAB-C4669-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2083
Antibody Isotype
IgG2a
Application
IF, WB

Basic Information

Immunogen
E. coli-derived human P cadherin recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)2 μg/ml
WB0.1-0.5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, 4mg Trehalose
Preservative
None
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cadherin 3
Introduction
CDH3 (Cadherin 3) is a Protein Coding gene. Diseases associated with CDH3 include Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome and Hypotrichosis, Congenital, With Juvenile Macular Dystrophy. Among its related pathways are ERK Signaling and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH1.
Entrez Gene ID
1001
UniProt ID
P22223
Alternative Names
Cadherin 3; Cadherin 3, Type 1, P-Cadherin (Placental); P-Cadherin; CDHP; Calcium-Dependent Adhesion Protein, Placental; Cadherin 3, P-Cadherin (Placental);
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Biological Process
Adherens junction organization Source: Reactome
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Hair cycle process Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keratinization Source: UniProtKB
Negative regulation of timing of catagen Source: UniProtKB
Negative regulation of transforming growth factor beta2 production Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of melanin biosynthetic process Source: UniProtKB
Positive regulation of melanosome transport Source: UniProtKB
Positive regulation of monophenol monooxygenase activity Source: UniProtKB
Regulation of hair cycle by canonical Wnt signaling pathway Source: UniProtKB
Response to drug Source: Ensembl
Retina homeostasis Source: UniProtKB
Visual perception Source: UniProtKB-KW
Wound healing Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Hypotrichosis congenital with juvenile macular dystrophy (HJMD): A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life.
Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS): A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.
Topology
Extracellular: 108-654
Helical: 655-677
Cytoplasmic: 678-829
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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