Mouse Anti-CDH3 Recombinant Antibody (CBXC-0309) (CBMAB-C4670-CQ)

Name: Mouse Anti-CDH3 Recombinant Antibody (CBXC-0309)
SKU: CBMAB-C4670-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-0309

Application

IHC, WB

Immunogen

Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue coupled to KLH.

Host Species

Mouse

Specificity

Chicken, Human, Mouse, Rabbit, Rat, Snake

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1-2 μg/ml
IHC	2-4 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 4mg Trehalose

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cadherin 3

Introduction

CDH3 (Cadherin 3) is a Protein Coding gene. Diseases associated with CDH3 include Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome and Hypotrichosis, Congenital, With Juvenile Macular Dystrophy. Among its related pathways are ERK Signaling and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH1.

Entrez Gene ID

1001

UniProt ID

P22223

Alternative Names

Cadherin 3; Cadherin 3, Type 1, P-Cadherin (Placental); P-Cadherin; CDHP; Calcium-Dependent Adhesion Protein, Placental; Cadherin 3, P-Cadherin (Placental);

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: Reactome
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Hair cycle process Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keratinization Source: UniProtKB
Negative regulation of timing of catagen Source: UniProtKB
Negative regulation of transforming growth factor beta2 production Source: UniProtKB
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of melanin biosynthetic process Source: UniProtKB
Positive regulation of melanosome transport Source: UniProtKB
Positive regulation of monophenol monooxygenase activity Source: UniProtKB
Regulation of hair cycle by canonical Wnt signaling pathway Source: UniProtKB
Response to drug Source: Ensembl
Retina homeostasis Source: UniProtKB
Visual perception Source: UniProtKB-KW
Wound healing Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Hypotrichosis congenital with juvenile macular dystrophy (HJMD): A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life.
Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS): A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.

Topology

Extracellular: 108-654
Helical: 655-677
Cytoplasmic: 678-829

Fang, X., Bai, Y., Zhang, L., & Ding, S. (2021). MicroRNA‑665 regulates the proliferation, apoptosis and adhesion of gastric cancer cells by binding to cadherin 3. Oncology Letters, 21(6), 1-12.

Han, S., Wang, Y., Ma, J., Wang, Z., Wang, H. M. D., & Yuan, Q. (2020). Sulforaphene inhibits esophageal cancer progression via suppressing SCD and CDH3 expression, and activating the GADD45B-MAP2K3-p38-p53 feedback loop. Cell death & disease, 11(8), 1-13.

Hsiao, T. F., Wang, C. L., Wu, Y. C., Feng, H. P., Chiu, Y. C., Lin, H. Y., ... & Yu, C. J. (2020). Integrative omics analysis reveals soluble cadherin-3 as a survival predictor and an early monitoring marker of EGFR tyrosine kinase inhibitor therapy in lung cancer. Clinical Cancer Research, 26(13), 3220-3229.

Chalise, U., & Lindsey, M. L. (2020). Cadherin‐3 and Catenin‐α2 are novel MMP‐12 substrates. The FASEB Journal, 34(S1), 1-1.

Nasser, F., Mulahasanovic, L., Alkhateeb, M., Biskup, S., Stingl, K., & Zrenner, E. (2019). Hypotrichosis with cone-rod dystrophy in a patient with cadherin 3 (CDH3) mutation. Documenta Ophthalmologica, 138(2), 153-160.

Kumara, H. S., Bellini, G. A., Caballero, O. L., Herath, S. A., Su, T., Ahmed, A., ... & Whelan, R. L. (2017). P-Cadherin (CDH3) is overexpressed in colorectal tumors and has potential as a serum marker for colorectal cancer monitoring. Oncoscience, 4(9-10), 139.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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