Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CNOT2 Recombinant Antibody (CBXC-2602) (V2LY-1206-LY456)


See all CNOT2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-2602
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human CNOT2 produced in E.coli.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:2,000
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 2
Entrez Gene ID
Human4848
Mouse72068
Rat299805
UniProt ID
HumanQ9NZN8
MouseQ8C5L3
RatA0A0G2K717
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Gene silencing by RNA Source: UniProtKB-KW
Negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: GO_Central
Positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
Regulation of stem cell population maintenance Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
Trophectodermal cell differentiation Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies (IDNADFS):
An autosomal dominant disorder characterized by delayed development, speech delay with nasal speech, and characteristic facial features including upslanted palpebral fissures, anteverted nares, a thin upper lip, and micrognathia. Some patients may have skeletal anomalies, such as brachydactyly, toe syndactyly and flat feet.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CNOT2 Recombinant Antibody (CBXC-2602)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry