Mouse Anti-CNOT2 Recombinant Antibody (2E10) (V2LY-1206-LY453)

Name: Mouse Anti-CNOT2 Recombinant Antibody (2E10)
SKU: V2LY-1206-LY453
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E10

Application

ELISA

Immunogen

CNOT2 (441 a.a. ~ 540 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CCR4-NOT Transcription Complex Subunit 2

Entrez Gene ID

4848

UniProt ID

Q9NZN8

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.

Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Gene silencing by RNA Source: UniProtKB-KW
Negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: GO_Central
Positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
Regulation of stem cell population maintenance Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
Trophectodermal cell differentiation Source: Ensembl

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies (IDNADFS):
An autosomal dominant disorder characterized by delayed development, speech delay with nasal speech, and characteristic facial features including upslanted palpebral fissures, anteverted nares, a thin upper lip, and micrognathia. Some patients may have skeletal anomalies, such as brachydactyly, toe syndactyly and flat feet.

Suzuki, T., Hoshina, M., Nishijima, S., Hoshina, N., Kikuguchi, C., Tomohiro, T., ... & Yamamoto, T. (2022). Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2. RNA biology, 19(1), 234-246.

Jung, J. H., Lee, D., Ko, H. M., & Jang, H. J. (2021). Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Biomolecules, 11(10), 1492.

Kim, E. O., Kang, S. E., Choi, M., Rhee, K. J., & Yun, M. (2020). CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. International journal of molecular medicine, 45(2), 324-332.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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