Mouse Anti-COLEC10 Recombinant Antibody (4C1) (CBMAB-C6708-LY)

Name: Mouse Anti-COLEC10 Recombinant Antibody (4C1)
SKU: CBMAB-C6708-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4C1

Application

ELISA

Immunogen

COLEC10 (121 a.a. ~ 229 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

collectin sub-family member 10 (C-type lectin)

Entrez Gene ID

10584

UniProt ID

Q9Y6Z7

Alternative Names

Collectin Subfamily Member 10; Collectin Sub-Family Member 10 (C-Type Lectin); Collectin Liver Protein 1; Collectin-34; CL-34; CLL1;

Function

Lectin that binds to various sugars: galactose> mannose = fucose> N-acetylglucosamine> N-acetylgalactosamine (PubMed:10224141).

Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481).

Biological Process

Complement activation Source: Reactome
Complement activation, lectin pathway Source: Reactome
Cranial skeletal system development Source: UniProtKB

Cellular Location

Golgi apparatus; Secreted; Cytoplasm

Involvement in disease

3MC syndrome 3 (3MC3):
A form of 3MC syndrome, an autosomal recessive disorder characterized by facial dysmorphism, craniosynostosis, learning disability, and genital, limb and vesicorenal anomalies. Facial features include hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.

Migliorero, M., Kalantari, S., Bracciamà, V., Sorbini, M., Arruga, F., Peruzzi, L., ... & Deaglio, S. (2021). A novel COLEC10 mutation in a child with 3MC syndrome. European journal of medical genetics, 64(12), 104374.

Zhang, B., & Wu, H. (2018). Decreased expression of COLEC10 predicts poor overall survival in patients with hepatocellular carcinoma. Cancer management and research, 10, 2369.

Munye, M. M., Diaz-Font, A., Ocaka, L., Henriksen, M. L., Lees, M., Brady, A., ... & Hernandez-Hernandez, V. (2017). COLEC10 is mutated in 3MC patients and regulates early craniofacial development. PLoS genetics, 13(3), e1006679.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-COLEC10 Recombinant Antibody (X0358) (CAT#: V2LY-1206-LY712)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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