COLEC10

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq]

Full Name

collectin sub-family member 10 (C-type lectin)

Function

Lectin that binds to various sugars: galactose> mannose = fucose> N-acetylglucosamine> N-acetylgalactosamine (PubMed:10224141).

Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481).

Biological Process

Complement activation Source: Reactome
Complement activation, lectin pathway Source: Reactome
Cranial skeletal system development Source: UniProtKB

Cellular Location

Golgi apparatus; Secreted; Cytoplasm

Involvement in disease

3MC syndrome 3 (3MC3):
A form of 3MC syndrome, an autosomal recessive disorder characterized by facial dysmorphism, craniosynostosis, learning disability, and genital, limb and vesicorenal anomalies. Facial features include hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.