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Mouse Anti-CSNK2B Recombinant Antibody (CBFYH-3400) (CBMAB-H3944-FY)

This product is mouse antibody that recognizes CSNK2B. The antibody CBFYH-3400 can be used for immunoassay techniques such as: WB, IHC-P.
See all CSNK2B antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Hamster, Rat
Clone
CBFYH-3400
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Purified recombinant human CK2 beta-subunit
Specificity
Cattle, Hamster, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Casein Kinase 2 Beta
Introduction
The Ly6g5b gene presents particular behaviours in its expression, involving an intron retention event and being capable to form RNA chimera transcripts with the upstream gene Csnk2b.
Entrez Gene ID
81650
UniProt ID
P67874
Alternative Names
Ck2
Function
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610).

Participates in Wnt signaling (By similarity).
Biological Process
Adiponectin-activated signaling pathway Source: BHF-UCL
Cellular protein-containing complex assembly Source: BHF-UCL
Endothelial tube morphogenesis Source: BHF-UCL
Macroautophagy Source: Reactome
Mitotic chromosome condensation Source: Reactome
Negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Peptidyl-threonine phosphorylation Source: CAFA
Phosphatidylcholine biosynthetic process Source: Reactome
Positive regulation of activin receptor signaling pathway Source: BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Protein folding Source: Reactome
Regulation of DNA binding Source: BHF-UCL
Regulation of signal transduction by p53 class mediator Source: Reactome
Signal transduction Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Nucleoplasm; Nucleus; Cytoplasm; Ficolin-1-rich granule lumen; Protein kinase CK2 complex; Secretory granule lumen
Involvement in disease
Poirier-Bienvenu neurodevelopmental syndrome (POBINDS):
An autosomal dominant neurodevelopmental disorder characterized by onset of seizures in infancy, developmental delay, impaired intellectual development, and poor or absent speech.
PTM
Phosphorylated by alpha subunit.

Wilke, M. V., Oliveira, B. M., Pereira, A., Doriqui, M. J. R., Kok, F., & Souza, C. F. (2022). Two different presentations of de novo variants of CSNK2B: two case reports. Journal of Medical Case Reports, 16(1), 1-6.

Selvam, P., Jain, A., Cheema, A., Atwal, H., Forghani, I., & Atwal, P. S. (2021). Poirier–Bienvenu neurodevelopmental syndrome: A report of a patient with a pathogenic variant in CSNK2B with abnormal linear growth. American Journal of Medical Genetics Part A, 185(2), 539-543.

Yu, S., Hu, Q., Fan, K., Yang, C., & Gao, Y. (2021). CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling. Journal of Cell Communication and Signaling, 15(3), 383-392.

Yu, S., Li, L., Cai, H., He, B., Gao, Y., & Li, Y. (2021). Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Yang, S., Wu, L., Liao, H., Lu, X., Zhang, X., Kuang, X., & Yang, L. (2021). Clinical and genetic analysis of six Chinese children with Poirier-Bienvenu neurodevelopmental syndrome caused by CSNK2B mutation. neurogenetics, 22(4), 323-332.

Li, J., Gao, K., Cai, S., Liu, Y., Wang, Y., Huang, S., ... & Jiang, Y. (2019). Germline de novo variants in CSNK2B in Chinese patients with epilepsy. Scientific reports, 9(1), 1-8.

Nakashima, M., Tohyama, J., Nakagawa, E., Watanabe, Y., Siew, C. N. G., Kwong, C. S., ... & Matsumoto, N. (2019). Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures. Journal of human genetics, 64(4), 313-322.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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