Sign in or Register   Sign in or Register
  |  

Mouse Anti-CXCL10 (AA 22-94) Recombinant Antibody (CBFYC-2493) (CBMAB-C2566-FY)

This product is mouse antibody that recognizes CXCL10. The antibody CBFYC-2493 can be used for immunoassay techniques such as: WB, Neut.
See all CXCL10 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYC-2493
Antibody Isotype
IgG1
Application
WB, Neut

Basic Information

Immunogen
E. coli-derived recombinant cotton rat CXCL10/IP-10/CRG-2, Ile22-Val94
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 22-94

Target

Full Name
C-X-C Motif Chemokine Ligand 10
Introduction
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Endotheliitis and Paracoccidioidomycosis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL9.
Entrez Gene ID
UniProt ID
Alternative Names
CXCL10
Function
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417).

Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity).

Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743).

In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757).

Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antiviral innate immune response Source: ARUK-UCL
Blood circulation Source: ProtInc
Cell-cell signaling Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to heat Source: Ensembl
Cellular response to lipopolysaccharide Source: MGI
Cellular response to virus Source: ARUK-UCL
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Endothelial cell activation Source: CACAO
G protein-coupled receptor signaling pathway Source: UniProtKB
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Muscle organ development Source: ProtInc
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of myoblast differentiation Source: Ensembl
Negative regulation of myoblast fusion Source: Ensembl
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of monocyte chemotaxis Source: CACAO
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Positive regulation of T cell migration Source: MGI
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Regulation of endothelial tube morphogenesis Source: CACAO
Regulation of T cell chemotaxis Source: CACAO
Response to auditory stimulus Source: Ensembl
Response to cold Source: Ensembl
Response to gamma radiation Source: Ensembl
Response to vitamin D Source: Ensembl
Signal transduction Source: ProtInc
T cell chemotaxis Source: UniProtKB
Cellular Location
Secreted
PTM
Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead.

Karimabad, M. N., Kounis, N. G., Hassanshahi, G., Hassanshahi, F., Mplani, V., Koniari, I., ... & Nadimi, A. E. (2021). The Involvement of CXC Motif Chemokine Ligand 10 (CXCL10) and Its Related Chemokines in the Pathogenesis of Coronary Artery Disease and in the COVID-19 Vaccination: A Narrative Review. Vaccines, 9(11), 1224.

Gao, J., Wu, L., Wang, S., & Chen, X. (2020). Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases. Mediators of Inflammation, 2020.

Imam, A. M., Hamed, A. M., Nasef, S. I., Hassan, A. M., & Omar, H. H. (2019). Biochemical analysis of CXC motif chemokine ligand 10 (CXCL10) as a biomarker in patients with rheumatoid arthritis. Egypt J Immunol, 26(2), 79-86.

Bradburn, S., McPhee, J., Bagley, L., Carroll, M., Slevin, M., Al-Shanti, N., ... & Murgatroyd, C. (2018). Dysregulation of CXC motif ligand 10 during aging and association with cognitive performance. Neurobiology of aging, 63, 54-64.

Ishiuchi, Y., Sato, H., Tsujimura, K., Kawaguchi, H., Matsuwaki, T., Yamanouchi, K., ... & Nedachi, T. (2018). Skeletal muscle cell contraction reduces a novel myokine, chemokine (CXC motif) ligand 10 (CXCL10): potential roles in exercise-regulated angiogenesis. Bioscience, biotechnology, and biochemistry, 82(1), 97-105.

Amin, M., Vakilian, A., Mahmoodi, M. H., Hassanshahi, G., Falahati-Pour, S. K., Dolatabadi, M. R., & Nadimi, A. E. (2017). Circulatory levels of CXC motif chemokine ligands 1, 9, and 10 are elevated in patients with ischemic stroke. The Eurasian journal of medicine, 49(2), 92.

Jiang, Q., Wang, F., Shi, L., Zhao, X., Gong, M., Liu, W., ... & Han, D. (2017). CXC motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis. Cell death & disease, 8(10), e3146-e3146.

Ke, Y., Dang, E., Shen, S., Zhang, T., Qiao, H., Chang, Y., ... & Wang, G. (2017). Semaphorin4D drives CD8+ T-Cell lesional trafficking in oral lichen planus via CXCL9/CXCL10 upregulations in oral keratinocytes. Journal of Investigative Dermatology, 137(11), 2396-2406.

Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., ... & Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13(6), 4224-4230.

Lang, S., Li, L., Wang, X., Sun, J., Xue, X., Xiao, Y., ... & Wang, J. (2017). CXCL10/IP-10 neutralization can ameliorate lipopolysaccharide-induced acute respiratory distress syndrome in rats. PLoS One, 12(1), e0169100.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-CXCL10 (AA 22-94) Recombinant Antibody (CBFYC-2493)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare