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Mouse Anti-CYSLTR2 Recombinant Antibody (CBLC209-LY) (V2LY-0125-LY1018)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBLC209-LY
Antibody Isotype
IgM, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 213-229 within an N-terminal cytoplasmic domain of CysLT2 Receptor of mouse.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cysteinyl Leukotriene Receptor 2
Entrez Gene ID
Mouse70086
Rat170926
UniProt ID
MouseQ920A1
RatQ924T9
Function
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4>> LTE4.
Biological Process
Cellular response to glucagon stimulus Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Neuropeptide signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-42
Helical: 43-63
Cytoplasmic: 64-72
Helical: 73-93
Extracellular: 94-123
Helical: 124-144
Cytoplasmic: 145-153
Helical: 154-174
Extracellular: 175-204
Helical: 205-225
Cytoplasmic: 226-245
Helical: 246-266
Extracellular: 267-286
Helical: 287-307
Cytoplasmic: 308-346
More Infomation

Ceraudo, E., Horioka, M., Mattheisen, J. M., Hitchman, T. D., Moore, A. R., Kazmi, M. A., ... & Huber, T. (2021). Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. Journal of Biological Chemistry, 296.

Trinh, H. K. T., Suh, D. H., Nguyen, T. V. T., Choi, Y., Park, H. S., & Shin, Y. S. (2019). Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 141, 17-23.

Duah, E., Teegala, L. R., Kondeti, V., Adapala, R. K., Keshamouni, V. G., Kanaoka, Y., ... & Paruchuri, S. (2019). Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis. Proceedings of the National Academy of Sciences, 116(1), 199-204.

Slater, K., Hoo, P. S., Buckley, A. M., Piulats, J. M., Villanueva, A., Portela, A., & Kennedy, B. N. (2018). Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma. Cancer and Metastasis Reviews, 37(2), 335-345.

Liu, T., Barrett, N. A., Kanaoka, Y., Yoshimoto, E., Garofalo, D., Cirka, H., ... & Boyce, J. A. (2018). Type 2 cysteinyl leukotriene receptors drive IL-33–dependent type 2 immunopathology and aspirin sensitivity. The Journal of Immunology, 200(3), 915-927.

Möller, I., Murali, R., Müller, H., Wiesner, T., Jackett, L. A., Scholz, S. L., ... & Griewank, K. G. (2017). Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi. Modern Pathology, 30(3), 350-356.

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For research use only. Not intended for any clinical use.

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