CYSLTR2

CYSLTR2 (Cysteinyl Leukotriene Receptor 2) is a Protein Coding gene. Diseases associated with CYSLTR2 include Melanoma, Uveal and Adenoid Hypertrophy. Among its related pathways are Endothelins and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cysteinyl leukotriene receptor activity. An important paralog of this gene is CYSLTR1.

Full Name

Cysteinyl Leukotriene Receptor 2

Function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4>> LTE4.

Biological Process

Cellular response to glucagon stimulus Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Neuropeptide signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-42
Helical: 43-63
Cytoplasmic: 64-72
Helical: 73-93
Extracellular: 94-123
Helical: 124-144
Cytoplasmic: 145-153
Helical: 154-174
Extracellular: 175-204
Helical: 205-225
Cytoplasmic: 226-245
Helical: 246-266
Extracellular: 267-286
Helical: 287-307
Cytoplasmic: 308-346