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Mouse Anti-DAND5 Recombinant Antibody (3D4) (V2LY-0125-LY1078)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D4
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5 produced in E.coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:2,000
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA, Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DAN Domain BMP Antagonist Family Member 5
Entrez Gene ID
199699
UniProt ID
Q8N907
Function
Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).
Biological Process
Atrial septum development Source: BHF-UCL
Determination of heart left/right asymmetry Source: BHF-UCL
Determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of nodal signaling pathway Source: BHF-UCL
Negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Sequestering of BMP in extracellular matrix Source: GO_Central
Sequestering of nodal from receptor via nodal binding Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: GO_Central
Ventricular septum development Source: BHF-UCL
Cellular Location
Secreted
More Infomation

Popovic, N., Hooker, E., Barabino, A., Flamier, A., Provost, F., Buscarlet, M., ... & Larrivée, B. (2021). COCO/DAND5 inhibits developmental and pathological ocular angiogenesis. EMBO molecular medicine, 13(3), e12005.

Minegishi, K., Rothé, B., Komatsu, K. R., Ono, H., Ikawa, Y., Nishimura, H., ... & Hamada, H. (2021). Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex. Nature Communications, 12(1), 1-17.

Maerker, M., Getwan, M., Dowdle, M. E., McSheene, J. C., Gonzalez, V., Pelliccia, J. L., ... & Schweickert, A. (2021). Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nature communications, 12(1), 1-15.

Jacinto, R., Sampaio, P., Roxo-Rosa, M., Pestana, S., & Lopes, S. S. (2021). Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Frontiers in Cell and Developmental Biology, 9, 756.

Inácio, J. M., von Gilsa Lopes, J., Silva, A. M., Cristo, F., Marques, S., Futschik, M. E., & Belo, J. A. (2021). DAND5 Inactivation Enhances Cardiac Differentiation in Mouse Embryonic Stem Cells. Frontiers in cell and developmental biology, 9, 846.

Zhu, X., Shi, C., Zhong, Y., Liu, X., Yan, Q., Wu, X., ... & Li, G. (2020). Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression. Development, 147(1), dev182469.

Inácio, J. M., Almeida, M., Cristo, F., & Belo, J. A. (2020). Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c. 455G> A alteration in DAND5. Stem Cell Research, 42, 101677.

Miao, X., Zhang, Y., Sun, J., Cui, S., Meng, Q., Zhu, K., ... & Wang, T. (2017). Elevated serum DAND5 is associated with metastasis and predicts poor prognosis in colorectal cancer. United European Gastroenterology Journal, 5(5), 725-734.

Cristo, F., Inacio, J. M., Rosas, G., Carreira, I. M., Melo, J. B., de Almeida, L. P., ... & Belo, J. A. (2017). Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration. Stem Cell Research, 25, 152-156.

Cristo, F., Inácio, J. M., de Almeida, S., Mendes, P., Martins, D. S., Maio, J., ... & Belo, J. A. (2017). Functional study of DAND5 variant in patients with congenital heart disease and laterality defects. BMC Medical Genetics, 18(1), 1-9.

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For research use only. Not intended for any clinical use.

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