DAND5

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

Full Name

DAN Domain BMP Antagonist Family Member 5

Function

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).

Biological Process

Atrial septum development Source: BHF-UCL
Determination of heart left/right asymmetry Source: BHF-UCL
Determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of nodal signaling pathway Source: BHF-UCL
Negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: GO_Central
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Sequestering of BMP in extracellular matrix Source: GO_Central
Sequestering of nodal from receptor via nodal binding Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: GO_Central
Ventricular septum development Source: BHF-UCL

Cellular Location

Secreted