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Mouse Anti-DBH Recombinant Monoclonal Antibody (1045) (CBMAB-1045-YC)


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Published Data
CBMAB-1045-YC-1
Mouse Anti-DBH Monoclonal Antibody (1045) (CBMAB-1045-YC) in WB
Acupuncture elevates the expression of dopamine-β-hydroxylase in hippocampus induced by 2VO. Sham: sham-operated group, 2VO + Acu: 2VO + acupuncture group, 2VO + Pla-acu: 2VO + placebo-acupuncture group. Values are expressed as means ± SEM. (n = 6 rats for each group.) ...View More
Xiao, L. Y., Yang, J. W., Wang, X. R., Ye, Y., Yang, N. N., Yan, C. Q., & Liu, C. Z. (2018). Acupuncture Rescues Cognitive Impairment and Upregulates Dopamine-β-Hydroxylase Expression in Chronic Cerebral Hypoperfusion Rats. BioMed Research International, 2018(1), 5423961. Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-1045-YC-2
Mouse Anti-DBH Monoclonal Antibody (1045) (CBMAB-1045-YC) in WB
Western blot analysis was performed in lysates of Jc1-infected cells treated for 72 h or not (Control) with 5 μM reserpine, using anti-HCV NS5A, anti-VMAT2, anti-DDC, anti-DBH or anti-β-actin antibodies. β-actin was used as loading control. ...View More
Mpekoulis, G., Tsopela, V., Panos, G., Siozos, V., Kalliampakou, K. I., Frakolaki, E., ... & Vassilaki, N. (2021). Association of hepatitis C virus replication with the catecholamine biosynthetic pathway. Viruses, 13(11), 2139. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Cat, Guinea pig, Rabbit, Cattle
Clone
1045
Antibody Isotype
IgG1, λ
Application
WB, IP, IF

Basic Information

Immunogen
Purified DBH from adrenal medulla homogenate of rat.
Host Species
Mouse
Specificity
Human, Cat, Guinea pig, Rabbit, Cattle
Antibody Isotype
IgG1, λ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
Dopamine Beta-Hydroxylase
Entrez Gene ID
Human1621
Cat101082957
Rabbit103347199
UniProt ID
HumanP09172
CatM3WEJ6
Function
Conversion of dopamine to noradrenaline.
Biological Process
Behavioral response to ethanol Source: Ensembl
Blood vessel remodeling Source: Ensembl
Catecholamine biosynthetic process Source: Reactome
Chemical synaptic transmission Source: ProtInc
Dopamine catabolic process Source: UniProtKB
Fear response Source: Ensembl
Glucose homeostasis Source: Ensembl
Homoiothermy Source: Ensembl
Leukocyte mediated immunity Source: Ensembl
Leukocyte migration Source: Ensembl
Locomotory behavior Source: Ensembl
Maternal behavior Source: Ensembl
Memory Source: Ensembl
Norepinephrine biosynthetic process Source: UniProtKB
Octopamine biosynthetic process Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of vasoconstriction Source: Ensembl
Regulation of cell population proliferation Source: Ensembl
Regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Response to amphetamine Source: Ensembl
Response to pain Source: Ensembl
Visual learning Source: Ensembl
Cellular Location
Soluble dopamine beta-hydroxylase: Secreted; Secretory vesicle lumen; Chromaffin granule lumen; Secretory vesicle membrane; Chromaffin granule membrane
Involvement in disease
Orthostatic hypotension 1 (ORTHYP1):
A form of orthostatic hypotension due to congenital dopamine beta-hydroxylase deficiency. Orthostatic hypotension, also known as postural hypotension, is a finding defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure occurring 3 minutes after a person has risen from supine to standing. Symptoms include dizziness, blurred vision, and sometimes syncope. ORTHYP1 is an autosomal recessive condition apparent from infancy or early childhood and characterized by low plasma and urinary levels of norepinephrine and epinephrine, and episodic hypoglycemia.
Topology
Cytoplasmic: 1-176
Helical: 17-37
Intragranular: 38-617
PTM
N-glycosylated.
Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
More Infomation

Hobgood, D. K. (2021). ABO B gene is associated with introversion personality tendancies through linkage with dopamine beta hydroxylase gene. Medical Hypotheses, 148, 110513.

Polasik, D., Konieczna, A., Terman, A., & Dybus, A. (2021). The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs. Acta Veterinaria Brno, 90(3), 295-299.

Wassenberg, T., Deinum, J., van Ittersum, F. J., Kamsteeg, E. J., Pennings, M., Verbeek, M. M., ... & Willemsen, M. A. (2021). Clinical presentation and long‐term follow‐up of dopamine beta hydroxylase deficiency. Journal of inherited metabolic disease, 44(3), 554-565.

Kundu, S., Saini, M., Dey, S. K., & Kundu, S. (2020). Dopamine Beta Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases. In Frontiers in Protein Structure, Function, and Dynamics (pp. 339-357). Springer, Singapore.

Barbanti, P., Guadagni, F., De Marchis, M. L., Ialongo, C., Egeo, G., Fofi, L., ... & Palmirotta, R. (2019). Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine. Neurological Sciences, 40(8), 1717-1724.

Shalev, N., Vangkilde, S., Neville, M. J., Tunbridge, E. M., Nobre, A. C., & Chechlacz, M. (2019). Dissociable catecholaminergic modulation of visual attention: differential effects of catechol-O-methyltransferase and dopamine beta-hydroxylase genes on visual attention. Neuroscience, 412, 175-189.

Tang, S., Yao, B., Li, N., Lin, S., & Huang, Z. (2018). Association of dopamine beta-hydroxylase polymorphisms with alzheimer’s disease, Parkinson’s disease and schizophrenia: evidence based on currently available loci. Cellular Physiology and Biochemistry, 51(1), 411-428.

Yamaguchi, H., Hopf, F. W., Li, S. B., & de Lecea, L. (2018). In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nature communications, 9(1), 1-8.

Cheng, W., Ka, Y. W., & Chang, C. C. (2017). Involvement of dopamine beta-hydroxylase in the neuroendocrine-immune regulatory network of white shrimp, Litopenaeus vannamei. Fish & Shellfish Immunology, 68, 92-101.

Bozek, T., Blazekovic, A., Perkovic, M. N., Jercic, K. G., Sustar, A., Smircic-Duvnjak, L., ... & Borovecki, F. (2017). The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus. Diabetology & metabolic syndrome, 9(1), 1-11.

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For research use only. Not intended for any clinical use.

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