Mouse Anti-DBH Recombinant Antibody (CBYCD-561) (CBMAB-D0293-YC)

Name: Mouse Anti-DBH Recombinant Antibody (CBYCD-561)
SKU: CBMAB-D0293-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCD-561

Application

IHC-P

Immunogen

Recombinant fragment (around aa200-400) of human Dopamine beta-Hydroxylase protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC-P	1-2 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

0.2 mg/ml

More Infomation

Target

Full Name

Dopamine Beta-Hydroxylase

Entrez Gene ID

1621

UniProt ID

P09172

Function

Conversion of dopamine to noradrenaline.

Biological Process

Behavioral response to ethanol Source: Ensembl
Blood vessel remodeling Source: Ensembl
Catecholamine biosynthetic process Source: Reactome
Chemical synaptic transmission Source: ProtInc
Dopamine catabolic process Source: UniProtKB
Fear response Source: Ensembl
Glucose homeostasis Source: Ensembl
Homoiothermy Source: Ensembl
Leukocyte mediated immunity Source: Ensembl
Leukocyte migration Source: Ensembl
Locomotory behavior Source: Ensembl
Maternal behavior Source: Ensembl
Memory Source: Ensembl
Norepinephrine biosynthetic process Source: UniProtKB
Octopamine biosynthetic process Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of vasoconstriction Source: Ensembl
Regulation of cell population proliferation Source: Ensembl
Regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Response to amphetamine Source: Ensembl
Response to pain Source: Ensembl
Visual learning Source: Ensembl

Cellular Location

Soluble dopamine beta-hydroxylase: Secreted; Secretory vesicle lumen; Chromaffin granule lumen; Secretory vesicle membrane; Chromaffin granule membrane

Involvement in disease

Orthostatic hypotension 1 (ORTHYP1):
A form of orthostatic hypotension due to congenital dopamine beta-hydroxylase deficiency. Orthostatic hypotension, also known as postural hypotension, is a finding defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure occurring 3 minutes after a person has risen from supine to standing. Symptoms include dizziness, blurred vision, and sometimes syncope. ORTHYP1 is an autosomal recessive condition apparent from infancy or early childhood and characterized by low plasma and urinary levels of norepinephrine and epinephrine, and episodic hypoglycemia.

Topology

Cytoplasmic: 1-176
Helical: 17-37
Intragranular: 38-617

PTM

N-glycosylated.
Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.

Hobgood, D. K. (2021). ABO B gene is associated with introversion personality tendancies through linkage with dopamine beta hydroxylase gene. Medical Hypotheses, 148, 110513.

Polasik, D., Konieczna, A., Terman, A., & Dybus, A. (2021). The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs. Acta Veterinaria Brno, 90(3), 295-299.

Wassenberg, T., Deinum, J., van Ittersum, F. J., Kamsteeg, E. J., Pennings, M., Verbeek, M. M., ... & Willemsen, M. A. (2021). Clinical presentation and long‐term follow‐up of dopamine beta hydroxylase deficiency. Journal of inherited metabolic disease, 44(3), 554-565.

Kundu, S., Saini, M., Dey, S. K., & Kundu, S. (2020). Dopamine Beta Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases. In Frontiers in Protein Structure, Function, and Dynamics (pp. 339-357). Springer, Singapore.

Barbanti, P., Guadagni, F., De Marchis, M. L., Ialongo, C., Egeo, G., Fofi, L., ... & Palmirotta, R. (2019). Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine. Neurological Sciences, 40(8), 1717-1724.

Shalev, N., Vangkilde, S., Neville, M. J., Tunbridge, E. M., Nobre, A. C., & Chechlacz, M. (2019). Dissociable catecholaminergic modulation of visual attention: differential effects of catechol-O-methyltransferase and dopamine beta-hydroxylase genes on visual attention. Neuroscience, 412, 175-189.

Tang, S., Yao, B., Li, N., Lin, S., & Huang, Z. (2018). Association of dopamine beta-hydroxylase polymorphisms with alzheimer’s disease, Parkinson’s disease and schizophrenia: evidence based on currently available loci. Cellular Physiology and Biochemistry, 51(1), 411-428.

Yamaguchi, H., Hopf, F. W., Li, S. B., & de Lecea, L. (2018). In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nature communications, 9(1), 1-8.

Cheng, W., Ka, Y. W., & Chang, C. C. (2017). Involvement of dopamine beta-hydroxylase in the neuroendocrine-immune regulatory network of white shrimp, Litopenaeus vannamei. Fish & Shellfish Immunology, 68, 92-101.

Bozek, T., Blazekovic, A., Perkovic, M. N., Jercic, K. G., Sustar, A., Smircic-Duvnjak, L., ... & Borovecki, F. (2017). The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus. Diabetology & metabolic syndrome, 9(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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