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Mouse Anti-DRD4 Recombinant Antibody (13A176) (CBMAB-D1688-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dopamine Receptor D4 (DRD4). The antibody can be used for immunoassay techniques, such as ICC, WB.
See all DRD4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13A176
Antibody Isotype
IgG1, κ
Application
ICC, WB

Basic Information

Immunogen
Synthetic linear peptide corresponding to human DRD4
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dopamine Receptor D4
Introduction
DRD4 is the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
Entrez Gene ID
1815
UniProt ID
P21917
Alternative Names
Dopamine Receptor D4; D(2C) Dopamine Receptor; Dopamine D4 Receptor; Seven Transmembrane Helix Receptor; D(4) Dopamine Receptor; D4DR;
Function
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383).

Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383).

Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Biological Process
Adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: UniProtKB
Adult locomotory behavior Source: BHF-UCL
Arachidonic acid secretion Source: BHF-UCL
Behavioral fear response Source: BHF-UCL
Behavioral response to cocaine Source: BHF-UCL
Behavioral response to ethanol Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Chemical synaptic transmission Source: GO_Central
Dopamine metabolic process Source: BHF-UCL
Dopamine receptor signaling pathway Source: BHF-UCL
Fear response Source: BHF-UCL
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Inhibitory postsynaptic potential Source: BHF-UCL
Negative regulation of protein secretion Source: BHF-UCL
Negative regulation of voltage-gated calcium channel activity Source: BHF-UCL
Positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Positive regulation of kinase activity Source: BHF-UCL
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of sodium:proton antiporter activity Source: BHF-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of dopamine metabolic process Source: BHF-UCL
Regulation of postsynaptic neurotransmitter receptor internalization Source: Ensembl
Response to amphetamine Source: BHF-UCL
Response to histamine Source: BHF-UCL
Rhythmic process Source: UniProtKB-KW
Social behavior Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 1-29
Helical: 30-50
Cytoplasmic: 51-71
Helical: 72-92
Extracellular: 93-110
Helical: 111-131
Cytoplasmic: 132-152
Helical: 153-173
Extracellular: 174-192
Helical: 193-213
Cytoplasmic: 214-346
Helical: 347-367
Extracellular: 368-382
Helical: 383-403
Cytoplasmic: 404-419
PTM
Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein.
Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane.

Chatterjee, S. K., & Mondal, P. R. (2021). Molecular evolution and genetic variation of exon 3 inside the dopamine receptor D4 (DRD4) gene sequences among the non-human primates. Gene Reports, 22, 101003.

Butler, P. M., Chiong, W., Perry, D. C., Miller, Z. A., Gennatas, E. D., Brown, J. A., ... & Seeley, W. W. (2019). Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia. NeuroImage: Clinical, 23, 101822.

Cherepkova, E. V., Maksimov, V. N., Kushnarev, A. P., Shakhmatov, I. I., & Aftanas, L. I. (2019). The polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes in the men with antisocial behaviour and mixed martial arts fighters. The World Journal of Biological Psychiatry, 20(5), 402-415.

Zhou, Y., Cao, C., He, L., Wang, X., & Zhang, X. C. (2019). Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. Elife, 8, e48822.

Gervasini, G., González, L. M., Gamero-Villarroel, C., Mota-Zamorano, S., Carrillo, J. A., Flores, I., & García-Herráiz, A. (2018). Effect of dopamine receptor D4 (DRD4) haplotypes on general psychopathology in patients with eating disorders. Gene, 654, 43-48.

Muda, R., Kicia, M., Michalak-Wojnowska, M., Ginszt, M., Filip, A., Gawda, P., & Majcher, P. (2018). The dopamine receptor D4 gene (DRD4) and financial risk-taking: Stimulating and instrumental risk-taking propensity and motivation to engage in investment activity. Frontiers in behavioral neuroscience, 12, 34.

Chang, C. H., Yu, C. J., Du, J. C., Chiou, H. C., Chen, H. C., Yang, W., ... & Chen, M. L. (2018). The interactions among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of dopamine receptor D4 increase the risk of attention deficit/hyperactivity disorder in children. Environmental Research, 160, 339-346.

Green, C. G., Babineau, V., Jolicoeur-Martineau, A., Bouvette-Turcot, A. A., Minde, K., Sassi, R., ... & Wazana, A. (2017). Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months. Development and psychopathology, 29(3), 901-917.

Park, A., Kim, J., Zaso, M. J., Glatt, S. J., Sher, K. J., Scott-Sheldon, L. A., ... & Carey, M. P. (2017). The interaction between the dopamine receptor D4 (DRD4) variable number tandem repeat polymorphism and perceived peer drinking norms in adolescent alcohol use and misuse. Development and psychopathology, 29(1), 173-183.

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For research use only. Not intended for any clinical use.

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