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Mouse Anti-DUSP16 Recombinant Antibody (3F3) (CBMAB-D1887-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dual Specificity Phosphatase 16 (DUSP16). The antibody can be used for immunoassay techniques, such as ELISA.
See all DUSP16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F3
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
DUSP16 (NP_085143.1, 561 a.a. ~ 665 a.a) partial recombinant protein with GST tag. The immunogen sequence: TESSHFYSAS AIYGGSASYS AYSCSQLPTC GDQVYSVRRR QKPSDRADSR RSWHEESPFE KQFKRRSCQM EFGESIMSEN RSREELGKVG SQSSFSGSME IIEVS
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 561-665

Target

Full Name
Dual Specificity Phosphatase 16
Introduction
DUSP16 is a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
Entrez Gene ID
80824
UniProt ID
Q9BY84
Alternative Names
Dual Specificity Phosphatase 16; Mitogen-Activated Protein Kinase Phosphatase 7; MAP Kinase Phosphatase 7; MAPK Phosphatase-7; MKP-7; MKP7;
Research Area
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Biological Process
Dephosphorylation Source: UniProtKB
Inactivation of MAPK activity Source: GO_Central
MAPK export from nucleus Source: UniProtKB
MAPK phosphatase export from nucleus, leptomycin B sensitive Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: GO_Central
Peptidyl-tyrosine dephosphorylation Source: GO_Central
Protein dephosphorylation Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Cytoplasmic vesicle. After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
PTM
Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.
(Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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