Mouse Anti-EBV LMP1 Recombinant Antibody (CBMW-H1390) (CBMAB-V208-1616-FY)

Name: Mouse Anti-EBV LMP1 Recombinant Antibody (CBMW-H1390)
SKU: CBMAB-V208-1616-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBMW-H1390

Application

FC, IHC, CyTOF

Immunogen

Purified plasma membranes from LMP1 expressing insect cells infected with a recombinant LMP1 baculovirus

Specificity

EBV

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Human gammaherpesvirus 4 Latent membrane protein 1

Introduction

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known viruses in the herpes family, and is one of the most common viruses in humans.

Entrez Gene ID

3783750

Alternative Names

LMP1; Latent membrane protein 1; EBV LMP1; Human gammaherpesvirus 4

Research Area

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Inhibits also host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2.

Biological Process

Activation by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Suppression by virus of host TRAF activity Source: UniProtKB-KW
Suppression by virus of host TYK2 activity Source: UniProtKB-KW
Suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Transformation of host cell by virus Source: InterPro

Cellular Location

Host cell membrane

Topology

Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-51
Helical: 52-72
Cytoplasmic: 73-75
Helical: 76-96
Extracellular: 97-106
Helical: 107-127
Cytoplasmic: 128-139
Helical: 140-160
Extracellular: 161-163
Helical: 164-184
Cytoplasmic: 185-386

PTM

Ubiquitinated on the N-terminus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-EBV LMP1 Recombinant Antibody (CBMW-H1390) (CAT#: V2LY-0425-LY1319)

Related Products

Mouse Anti-EBV LMP1 Recombinant Antibody (CBMW-H1390) (CAT#: V2LY-0425-LY1319)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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