EBV LMP1

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.

Full Name

Human gammaherpesvirus 4 Latent membrane protein 1

Research Area

Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Inhibits also host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2.

Biological Process

Activation by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Suppression by virus of host TRAF activity Source: UniProtKB-KW
Suppression by virus of host TYK2 activity Source: UniProtKB-KW
Suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
Transformation of host cell by virus Source: InterPro

Cellular Location

Host cell membrane

Topology

Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-51
Helical: 52-72
Cytoplasmic: 73-75
Helical: 76-96
Extracellular: 97-106
Helical: 107-127
Cytoplasmic: 128-139
Helical: 140-160
Extracellular: 161-163
Helical: 164-184
Cytoplasmic: 185-386

PTM

Ubiquitinated on the N-terminus.