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Mouse Anti-ECSIT (AA 20-431) Recombinant Antibody (CBFYE-0416) (CBMAB-E0731-FY)

This product is mouse antibody that recognizes ECSIT. The antibody CBFYE-0416 can be used for immunoassay techniques such as: ELISA, PLA.
See all ECSIT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0416
Antibody Isotype
IgG2a, κ
Application
ELISA, PLA

Basic Information

Immunogen
Full length recombinant corresponding to aa20-432 from human SITPEC with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 20-431

Target

Full Name
ECSIT homolog (Drosophila)
Introduction
ECSIT (ECSIT Signalling Integrator) is a Protein Coding gene. Diseases associated with ECSIT include Dental Pulp Disease. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and oxidoreductase activity, acting on NAD(P)H.
Entrez Gene ID
51295
UniProt ID
Q9BQ95
Alternative Names
ECSIT Signalling Integrator; Likely Ortholog Of Mouse Signaling Intermediate In Toll Pathway Evolutionarily Conserved; Signaling Intermediate In Toll Pathway Evolutionarily Conserved Ortholog (Mouse); Evolutionarily Conserved Signaling Intermediate In Toll Pathway, Mitochondrial; ECSIT Homolog (Drosophila); Protein SITPEC; ECSIT Homolog; SITPEC
Research Area
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).

Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Biological Process
Innate immune response Source: UniProtKB-KW
Regulation of oxidoreductase activity Source: UniProtKB
Regulation of protein complex stability Source: UniProtKB
Cellular Location
Nucleus; Mitochondrion; Cytoplasm

Chaitanya, N. S., Tammineni, P., Nagaraju, G. P., & Reddy, A. B. (2022). Pleiotropic roles of evolutionarily conserved signaling intermediate in toll pathway (ECSIT) in pathophysiology. Journal of Cellular Physiology.

Qi, Z., Pi, X., Xu, Y., Zhang, Q., Wangkahart, E., Meng, F., & Wang, Z. (2022). Molecular characterization of the evolutionary conserved signaling intermediate in Toll pathways (ECSIT) of soiny mullet (Liza haematocheila). Fish & Shellfish Immunology.

Hu, Y., Liu, W., Zhang, X., & Liu, D. (2022). ECSIT inhibits cell death to increase tumor progression and metastasis via p53 in human breast cancer. Translational Cancer Research, 11(4), 699.

Xu, L., Humphries, F., Delagic, N., Wang, B., Holland, A., Edgar, K. S., ... & Moynagh, P. N. (2021). ECSIT is a critical limiting factor for cardiac function. JCI insight, 6(12).

Ge, Q., Wang, J., Li, J., & Li, J. (2021). Identification, characterization, and functional analysis of Toll and ECSIT in Exopalaemon carinicauda. Developmental & Comparative Immunology, 116, 103926.

Kim, M. J., Min, Y., Kwon, J., Son, J., Im, J. S., Shin, J., & Lee, K. Y. (2019). p62 negatively regulates TLR4 signaling via functional regulation of the TRAF6-ECSIT complex. Immune Network, 19(3).

Kim, M. J., Min, Y., Shim, J. H., Chun, E., & Lee, K. Y. (2019). CRBN is a negative regulator of bactericidal activity and autophagy activation through inhibiting the ubiquitination of ECSIT and BECN1. Frontiers in immunology, 10, 2203.

Wen, H., Ma, H., Cai, Q., Lin, S., Lei, X., He, B., ... & Liu, Q. (2018). Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma. Nature medicine, 24(2), 154-164.

Carneiro, F. R., Lepelley, A., Seeley, J. J., Hayden, M. S., & Ghosh, S. (2018). An essential role for ECSIT in mitochondrial complex I assembly and mitophagy in macrophages. Cell reports, 22(10), 2654-2666.

Wang, H., Behrens, E. M., Pignolo, R. J., & Kaplan, F. S. (2018). ECSIT links TLR and BMP signaling in FOP connective tissue progenitor cells. Bone, 109, 201-209.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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