ECSIT

ECSIT (ECSIT Signalling Integrator) is a Protein Coding gene. Diseases associated with ECSIT include Dental Pulp Disease. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and oxidoreductase activity, acting on NAD(P)H.

Full Name

ECSIT homolog (Drosophila)

Research Area

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).

Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.

Biological Process

Innate immune response Source: UniProtKB-KW
Regulation of oxidoreductase activity Source: UniProtKB
Regulation of protein complex stability Source: UniProtKB

Cellular Location

Nucleus; Mitochondrion; Cytoplasm